865715-91-9Relevant articles and documents
Synthesis of macrocyclic urea kinase inhibitors
Tao, Zhi-Fu,Sowin, Thomas J.,Lin, Nan-Horng
, p. 2855 - 2858 (2008/03/13)
An efficient and convergent route was developed for the synthesis of a novel class of urea-based macrocyclic kinase inhibitors. The synthesis is featured with an efficient urea formation by using a key carbamate intermediate and with a smooth ring-closure olefin metathesis. Furthermore, the hydrogenations of the resulting olefins were investigated in this complex macrocyclic ring system. Georg Thieme Verlag Stuttgart.