865853-22-1

Basic information

• Product Name: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
• Synonyms: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
• CAS NO: 865853-22-1
• Molecular Weight: 537.89
• Mol File: 865853-22-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester(865853-22-1)
• EPA Substance Registry System: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester(865853-22-1)

Safety Data

• Hazardous Substances Data: 865853-22-1(Hazardous Substances Data)

Upstream product

• 865853-21-0 (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 865853-20-9 (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 20160-60-5 2-(trimethylsilyl)-ethoxycarbonyl chloride 

Downstream Products

• 130-95-0 quinine 
• 56-54-2 quinindine 

Relevant articles and documents

Improved synthesis of quinine alkaloids with the Teoc protective group

TeocCl (Teoc: C(O)O(CH2)2TMS) generated in situ was conveniently used for trans-protection of the N-Bn piperidine intermediate to N-Teoc piperidine. Later, deprotection of the Teoc group and the subsequent quinuclidine ring formation was achieved with CsF in a domino fashion to afford the quinine alkaloids.