866-72-8

Basic information

• Product Name: 2,2,4-trimethylpentanoic acid
• CAS NO: 866-72-8
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.2114
• Mol File: 866-72-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 223.8°C at 760 mmHg
• Flash Point: 99.4°C
• Density: 0.926g/cm³
• Vapor Pressure: 0.0348mmHg at 25°C
• Refractive Index: 1.434
• CAS DataBase Reference: 2,2,4-trimethylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,4-trimethylpentanoic acid(866-72-8)
• EPA Substance Registry System: 2,2,4-trimethylpentanoic acid(866-72-8)

Safety Data

• Hazardous Substances Data: 866-72-8(Hazardous Substances Data)

Usage

Physical properties

White, crystalline solid with a strong odor 2,2,4-trimethylpentanoic acid is a white, crystalline solid that has a strong odor.

Solubility

Soluble in water, alcohol, and ether 2,2,4-trimethylpentanoic acid is soluble in water, alcohol, and ether, which means it can dissolve in these solvents and form a homogeneous solution.

Uses

Precursor in the production of pharmaceuticals, agrochemicals, and fragrances 2,2,4-trimethylpentanoic acid is used as a precursor, or starting material, in the production of various products such as pharmaceuticals, agrochemicals, and fragrances.

Corrosion inhibitor and stabilizer

Used in the manufacturing of plastics and synthetic rubbers 2,2,4-trimethylpentanoic acid is also used as a corrosion inhibitor and as a stabilizer in the manufacturing of plastics and synthetic rubbers.

Derivatives

Used in the production of plasticizers, lubricants, and metalworking fluids Derivatives of 2,2,4-trimethylpentanoic acid are used in the production of various products such as plasticizers, lubricants, and metalworking fluids.

Toxicity

Relatively low in toxicity 2,2,4-trimethylpentanoic acid is considered to be relatively low in toxicity, which means it is not highly poisonous or harmful to living organisms.

Health hazards

Can cause irritation to the respiratory tract and skin Prolonged exposure to the vapor or dust of 2,2,4-trimethylpentanoic acid can cause irritation to the respiratory tract and skin, which means it can cause discomfort or harm to these parts of the body.

Upstream product

• 258345-29-8 3,3,5-trimethyl-hexan-2-one 
• 90227-07-9 2,2,4-trimethyl-valeric acid amide 
• 91242-87-4 2,4,4,6-tetramethyl-heptan-3-one 
• 64-18-6 formic acid 
• 625-06-9 2,4-dimethyl-2-pentanol 
• 7697-37-2 nitric acid 
• 872280-98-3 2,3,5-trimethyl-hexane-2,3-diol 
• 69462-10-8 2,2,4-Trimethyl-valeriansaeurenitril 
• 61067-15-0 2,2,4-Trimethyl-1-phenyl-pentanon-⁽¹⁾ 
• 78-77-3 Isobutyl bromide 
• 79-31-2 isobutyric Acid 
• 547-63-7 Methyl isobutyrate 

Downstream Products

• 123-44-4 2,2,4-trimethyl-1-pentanol 

Relevant articles and documents

Hypervalent Iodine(III)-Mediated Decarboxylative Ritter-Type Amination Leading to the Production of α-Tertiary Amine Derivatives

α-Tertiary amines (ATAs) are attractive structural motifs that are frequently found in biologically active molecules. Therefore, the development of an efficient method for the synthesis of ATAs represents an important research topic in the field of medicinal chemistry as well as organic chemistry. Although the Ritter reaction is a reliable approach for preparing α-tertiary amine derivatives via intermolecular amination reactions, the typical methods suffer from disadvantages such as harsh reaction conditions and the use of strong acids. Because of this, it has been of limited use in the synthesis of ATAs. We report here on the decarboxylative Ritter-type amination of carboxylic acids bearing an α-quaternary carbon center using a combination of PhI(OAc)2 and molecular iodine (I2) to produce the corresponding α-tertiary amine derivatives. This reaction proceeded at ambient temperature on the benchtop with a fluorescent light. Mechanistic investigations suggest that the reaction proceeds via the formation of an alkyl iodide and a higher oxidation state iodine(III) species as key intermediates. Similarly, a stepwise protocol for the Ritter-type amination of alcohols via the formation of oxalic acid monoalkyl esters was also achieved. The present methods represent a useful tool for the synthesis of ATAs that are difficult to prepare by conventional methods.

HIGHLY SELECTIVE SYNTHESIS OF ACYCLIC TERT-ALIPHATIC CARBOXYLIC ACIDS FROM ACYCLIC TERT-ALCOHOLS USING SULFURIC ACID SUPERSATURATED WITH CARBON MONOXIDE

The selective carboxylation of acyclic tert-aliphatic alcohols was successfully performed to produce the corresponding acyclic tert-aliphatic carboxylic acids in significantly high yields using concentrated sufuric acid supersaturated with carbon monoxide.