866022-28-8 Usage
Description
Bischloroanthrabenzoxocinone, also known as (-)BABX, is a selective inhibitor of Type II fatty acid synthesis (FASII). It has shown potent antibacterial activities against both S. aureus and E. coli, with IC50 values of 11.4 and 35.3 μg/ml, respectively. Type II fatty acid synthesis is essential for bacterial cell viability, making it a promising target for the development of novel antibiotics. Additionally, (-)BABX has been shown to inhibit agonist binding to Liver X receptors (LXR), which regulate the expression of the ABCA1 gene responsible for cholesterol efflux from cells.
Uses
Used in Pharmaceutical Industry:
Bischloroanthrabenzoxocinone is used as a selective inhibitor of Type II fatty acid synthesis (FASII) for its potential as a novel antibiotic agent. Its ability to target essential bacterial cell viability makes it a promising candidate for the development of new antimicrobial drugs to combat drug-resistant infections.
Used in Cholesterol Regulation:
Bischloroanthrabenzoxocinone is used as an inhibitor of agonist binding to Liver X receptors (LXR) for its role in regulating cholesterol homeostasis. By inhibiting LXR, (-)BABX can modulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells, potentially contributing to the management of cholesterol-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 866022-28-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,0,2 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 866022-28:
(8*8)+(7*6)+(6*6)+(5*0)+(4*2)+(3*2)+(2*2)+(1*8)=168
168 % 10 = 8
So 866022-28-8 is a valid CAS Registry Number.
866022-28-8Relevant articles and documents
Aromatic polyketone compounds, and synthesis method and application thereof
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Paragraph 0238; 0346-0355, (2021/07/01)
The invention discloses a synthesis method of aromatic polyketone products and analogues thereof. Intermolecular Diels-Alder reaction is performed on a formula 1a and a formula 2a to prepare a formula 3a, and a formula 4a is protected by using an ether ad
