866037-61-8Relevant articles and documents
Mimicking Enzymes: Asymmetric Induction inside a Carbamate-Based Steroidal Cleft
Concellón, Carmen,Martín, Judith,Gallegos, Miguel,Fanjul-Mosteirín, Noé,Costales, Aurora,Pendás, ángel Martín,Del Amo, Vicente
supporting information, p. 3994 - 3997 (2019/06/17)
Cholic acid has been elaborated into a carbamate-based tripodal architecture, which is able to promote an asymmetric organic transformation inside its chiral cavity. The nature of this steroidal catalyst has been disclosed by quantum-chemical calculations. It comprises the preorganization and confinement of the reagents within the cavity of the steroid to form a supramolecular complex held together by means of cooperative H-bond contacts. This operational mode resembles that of some enzymes.