86606-04-4

Basic information

• Product Name: 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)-
• CAS NO: 86606-04-4
• Molecular Formula: C8H13BrO2
• Molecular Weight: 221.094
• Mol File: 86606-04-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)-(86606-04-4)
• EPA Substance Registry System: 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)-(86606-04-4)

Safety Data

• Hazardous Substances Data: 86606-04-4(Hazardous Substances Data)

Usage

General Description

2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)- is a chemical compound with the molecular formula C7H11BrO2. It is a clear, colorless liquid that is commonly used in organic synthesis and as a reagent in chemical reactions. 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)- is also known for its distinctive odor and is used in the production of various fragrances and flavors. It is important to handle this chemical with caution as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes. Additionally, it is flammable and should be stored and handled properly to prevent accidents.

Upstream product

• 13991-36-1 4-bromocrotonic acid 
• 115-11-7 isobutene 
• 79218-15-8 tert-butyl (E)-crotonate 

Downstream Products

• 14036-55-6 t-butyl vinylacetate 
• 50745-75-0 2-(1-Hydroxy-cyclohexyl)-but-3-enoic acid tert-butyl ester 
• 129397-30-4 (1R,2R)-2-((S)-tert-Butoxycarbonyl-dibenzylamino-methyl)-cyclopropanecarboxylic acid tert-butyl ester 
• 178977-57-6 tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate 
• 182486-31-3 (2E,7E)-(5R,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic acid tert-butyl ester 
• 845749-03-3 4-(2-formyl-5-methoxy-phenoxy)-but-2-enoic acid tert-butyl ester 
• 845749-01-1 4-(2-formyl-6-methyl-phenoxy)-but-2-enoic acid tert-butyl ester 
• 845749-02-2 4-(2-formyl-4-methoxy-phenoxy)-but-2-enoic acid tert-butyl ester 
• 845748-99-4 4-(2-formyl-phenoxy)-but-2-enoic acid tert-butyl ester 
• 845749-00-0 4-(2-formyl-4-methyl-phenoxy)-but-2-enoic acid tert-butyl ester 
• 182486-11-9 2,4-Dinitro-benzoic acid (E)-(1S,2R)-1-((E)-3-tert-butoxycarbonyl-allyl)-2-methyl-4-phenyl-but-3-enyl ester 
• 182486-25-5 tert-butyl (5S,6R)-5-[(2S)-2-[(2R)-3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]-2-methylpropionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 

Relevant articles and documents

SPIROCYCLIC TETRAHYDROQUINAZOLINES

Provided are compounds represented by Formula I, wherein R3, A, A1, A2, A3, E, E1, E2, L, Q, Z, and (aa) are as defined in the specification, and the pharmaceutically acceptable salts and solvates thereof. Compounds of Formula (I) are KRAS inhibitors and are thus useful to treat cancer and other diseases.

NAPHTHYRIDINE DERIVATIVES AS ALPHA V BETA 6 INTEGRIN ANTAGONISTS FOR THE TREATMENT OF E.G. FIBROTIC DISEASES

A compound of formula (I) or a salt thereof wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono-or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono-or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H- pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1- yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H- pyrazol-1-yl or 1H- pyrazol-1-yl.

Access to Polyfunctionalized Chiral Piperidines through Enantioselective Addition-Carbocyclization Cascade Reaction Catalyzed by a Rhodium(I)-Diene Complex

A new addition-carbocyclization cascade reaction initiated by arylboronic acids and catalyzed by a rhodium/chiral diene complex is described. Starting from N-bridged oxoenoate derivatives, highly functionalized piperidines bearing three contiguous stereogenic centers were obtained with excellent enantio- and diastereoselectivities.