866186-93-8

Basic information

• Product Name: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide
• Synonyms: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide
• CAS NO: 866186-93-8
• Molecular Weight: 534.593
• Mol File: 866186-93-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide(866186-93-8)
• EPA Substance Registry System: N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide(866186-93-8)

Safety Data

• Hazardous Substances Data: 866186-93-8(Hazardous Substances Data)

Upstream product

• 4299-70-1 D-Tryptophan methyl ester 
• 153-94-6 D-tryptophan 
• 866186-92-7 methyl ((2-nitrophenyl)sulfonyl)-D-tryptophanate 
• 140645-39-2 3-(1H-indol-3-yl)-2-(2-nitro-benzenesulfonylamino)-propionic acid 
• 18881-17-9 (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 74163-81-8 L-Tic-OH 

Relevant articles and documents

Utilizing the intramolecular Fukuyama-Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design

We report the synthesis of the novel scaffolds pyrazino[1,2-b]isoquinoline and pyrrolo[1,2-a]pyrazine displaying the somatostatin pharmacophores. Both classes of compounds contain a pyrazine heterocycle, which can be prepared in a straightforward manner utilizing an intramolecular Fukuyama-Mitsunobu reaction. As both the families derive from amino acids, they can be accessed in high optical purity.