866211-50-9Relevant articles and documents
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Yoshikawa, Masato,Kamisaki, Haruhi,Kunitomo, Jun,Oki, Hideyuki,Kokubo, Hironori,Suzuki, Akihiro,Ikemoto, Tomomi,Nakashima, Kosuke,Kamiguchi, Naomi,Harada, Akina,Kimura, Haruhide,Taniguchi, Takahiko
, p. 7138 - 7149 (2015/11/16)
Highly potent and brain-penetrant phosphodiesterase 10A (PDE10A) inhibitors based on the 2-oxindole scaffold were designed and synthesized. (2-Oxo-1,3-oxazolidin-3-yl)phenyl derivative 1 showed the high P-glycoprotein (P-gp) efflux (efflux ratio (ER) = 6.
Progesterone receptor antagonists, contraceptive regimens, and kits
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Page/Page column 10, (2010/02/15)
A method of contraception is provided which involves delivery of 21 to 27 consecutive days of one or more PR antagonists in the absence of a progestin, estrogen, or other steroidal compound, followed by 1 to 7 days without any active agent. Also described is a pharmaceutically useful kit to facilitate delivery of this regimen.