866430-96-8

Basic information

• Product Name: (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester
• Synonyms: (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester
• CAS NO: 866430-96-8
• Molecular Weight: 503.596
• Mol File: 866430-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester(866430-96-8)
• EPA Substance Registry System: (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester(866430-96-8)

Safety Data

• Hazardous Substances Data: 866430-96-8(Hazardous Substances Data)

Upstream product

• 959984-64-6 (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate 
• 82834-12-6 N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine 

Downstream Products

• 82834-16-0 Perindopril 

Relevant articles and documents

Process for the preparation of perindopril and salts thereof

The present invention describes a novel method for the synthesis of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid, or of one of its aryl esters of formula XIII wherein X and Y are a hydrogen atom, a halogen, alkyl, alkoxyl or nitro group, and the conversion of the paranitrobenzyl ester of formula X into Perindopril of formula I or one of its salts.