866461-49-6Relevant articles and documents
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Olson, Steven,Aster, Susan D.,Brown, Kai,Carbin, Linda,Graham, Donald W.,Hermanowski-Vosatka, Anne,LeGrand, Cheryl B.,Mundt, Steven S.,Robbins, Michael A.,Schaeffer, James M.,Slossberg, Llnon H.,Szymonifka, Michael J.,Thieringer, Rolf,Wright, Samuel D.,Balkovec, James M.
, p. 4359 - 4362 (2007/10/03)
Adamantyl triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure-activity relationships of these inhibitors are presented.
