866553-38-0

Basic information

• Product Name: 2-(benzyloxycarbonyl-methyl-amino)-3,3,3-trifluoro-2-(4-phenoxy-benzenesulfonylmethyl)-propionic acid ethyl ester
• CAS NO: 866553-38-0
• Molecular Weight: 565.567
• Mol File: 866553-38-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxycarbonyl-methyl-amino)-3,3,3-trifluoro-2-(4-phenoxy-benzenesulfonylmethyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxycarbonyl-methyl-amino)-3,3,3-trifluoro-2-(4-phenoxy-benzenesulfonylmethyl)-propionic acid ethyl ester(866553-38-0)
• EPA Substance Registry System: 2-(benzyloxycarbonyl-methyl-amino)-3,3,3-trifluoro-2-(4-phenoxy-benzenesulfonylmethyl)-propionic acid ethyl ester(866553-38-0)

Safety Data

• Hazardous Substances Data: 866553-38-0(Hazardous Substances Data)

Upstream product

• 866553-34-6 2-benzyloxycarbonylamino-3,3,3-trifluoro-2-(4-phenoxy-benzenesulfonylmethyl)-propionic acid ethyl ester 
• 74-88-4 methyl iodide 
• 108-95-2 phenol 
• 126535-92-0 ethyl 2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate 
• 21134-15-6 1-(4-(methylsulfonyl)phenoxy]benzene 

Relevant articles and documents

Synthesis of α-trifluoromethyl-α-amino-β-sulfone hydroxamates: Novel nanomolar inhibitors of matrix metalloproteinases

The racemic α-trifluoromethyl-α-amino-β-sulfone hydroxamates 1 were synthesized by means of a nucleophilic addition of sulfur-stabilized carbanions to a N-Cbz imine of trifluoropyruvate (4). The free amino derivative 1a was the most potent inhibitor of both MMP-3 (stromelysin-1) and MMP-9 (gelatinase-B), showing an IC50 = 14 nM and 1 nM, respectively, and excellent selectivity versus MMP-1 (>5000-fold difference in inhibitory capacity). The N-Me derivative 1b was the most selective for MMP-3 with respect to MMP-9 (62-fold difference).