866848-94-4

Basic information

• Product Name: 6-Bromo-1,1-(ethylenedioxo)-indane
• Synonyms: 6-Bromo-indan-1-one 1,2-ethanediol ketal
• CAS NO: 866848-94-4
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.11
• Mol File: 866848-94-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Bromo-1,1-(ethylenedioxo)-indane(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1,1-(ethylenedioxo)-indane(866848-94-4)
• EPA Substance Registry System: 6-Bromo-1,1-(ethylenedioxo)-indane(866848-94-4)

Safety Data

• Hazardous Substances Data: 866848-94-4(Hazardous Substances Data)

Usage

General Description

6-Bromo-1,1-(ethylenedioxo)-indane, also known as BDID, is a chemical compound with a molecular formula of C10H9BrO2. It is a brominated indane derivative and is used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. BDID has been studied as a potential anti-tumor agent and has shown promising activity in inhibiting the growth of cancer cells. It is also used as a reagent in chemical research and has been investigated for its potential use in the development of new types of materials. However, due to its synthetic nature and potential health hazards, proper safety precautions should be taken when handling and using this compound.

Upstream product

• 14548-39-1 6-bromoindan-1-one 
• 107-21-1 ethylene glycol 

Downstream Products

• 954238-34-7 2',3'-dihydrospiro[[1,3]dioxolane-2,1'-indene]-6'-carbaldehyde 
• 193819-51-1 6-(hydroxymethyl)-1-indanone 
• 866849-00-5 (2',3'-dihydrospiro[[1,3]dioxolane-2,1'-indene]-6'-yl)methanol 
• 60031-08-5 Indan-1-one-6-carboxylic acid 

Relevant articles and documents

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

The optimization, based on computational, thermodynamic, and crystallographic data, of a series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of human immunodeficiency virus (HIV) has been achieved. Importantly, biological evaluation revealed that the small-molecule CD4 mimics (4-7) inhibit HIV-1 entry into target cells with both significantly higher potency and neutralization breadth than previous congeners, while maintaining high selectivity for the target virus. Their binding mode was characterized via thermodynamic and crystallographic studies.

TRICYCLIC PYRAZOLE KINASE INHIBITORS

Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.