867153-59-1

Basic information

• Product Name: (2S,3S)-4-Morpholin-4-yl-1-phenyl-3-((R)-1-phenyl-ethylamino)-butan-2-ol
• CAS NO: 867153-59-1
• Molecular Weight: 354.492
• Mol File: 867153-59-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-4-Morpholin-4-yl-1-phenyl-3-((R)-1-phenyl-ethylamino)-butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-4-Morpholin-4-yl-1-phenyl-3-((R)-1-phenyl-ethylamino)-butan-2-ol(867153-59-1)
• EPA Substance Registry System: (2S,3S)-4-Morpholin-4-yl-1-phenyl-3-((R)-1-phenyl-ethylamino)-butan-2-ol(867153-59-1)

Safety Data

• Hazardous Substances Data: 867153-59-1(Hazardous Substances Data)

Upstream product

• 397849-98-8 N-[(R)-(+)-α-methylbenzyl]aziridine-2-(S)-carboxylic acid menthyl ester 
• 867150-63-8 2-phenyl-1-((S)-1-((R)-1-phenylethyl)aziridine-2-yl)ethanone 
• 853056-96-9 N-[(R)-α-methylbenzyl]-(2S)-aziridine-(N'-methoxy-N'-methyl)carboxamide 
• 110-91-8 morpholine 
• 867150-82-1 (S)-2-Phenyl-1-[(S)-1-((R)-1-phenyl-ethyl)-aziridin-2-yl]-ethanol 

Relevant articles and documents

Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases

Sphingosine 1-phosphate (S1P), a product of sphingosine kinases (SphK), mediates diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis. In an effort to search and identify specific inhibitors of human SphK, the inhibitory effects of synthetic sphingoid analogs on kinase activity were examined. Among the analogs tested, we found two, SG12 and SG14, that have specific inhibitory effects on hSphK2. N,N-Dimethylsphingosine (DMS), a well-known SphK inhibitor, displayed inhibitory effects for both SphK1 and SphK2, as well as protein kinase C. In contrast, SG12 and SG14 exhibited selective inhibitory effects on hSphK2. Furthermore, SG14 did not affect PKC. In isolated platelets, SG14 blocked the conversion of sphingosine into sphingosine 1-phosphate significantly. This is the first report on the identification of a hSphK2-specific inhibitor, which may provide a useful tool for studying the biological functions of hSphK2.