86718-16-3

Basic information

• Product Name: 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester
• Synonyms: 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester
• CAS NO: 86718-16-3
• Molecular Formula: C₁₂H₁₄N₂O₆
• Molecular Weight: 282.24936
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 86718-16-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester(86718-16-3)
• EPA Substance Registry System: 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester(86718-16-3)

Safety Data

• Hazardous Substances Data: 86718-16-3(Hazardous Substances Data)

Usage

Chemical Properties

4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester is Yellow Solid

Uses

4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester is a reactant used in the preparation Cinitapride (C441990) and 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with antiemetic and gastroprokinetic activities.

Upstream product

• 59-06-3 methyl 4-acetamido-2-ethoxybenzoate 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 86718-17-4 methyl 4-amino-2-ethoxy-5-nitrobenzoate 

Relevant articles and documents

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with a medium perhydroazacycle ring in the amine moiety were prepared, and their antiemetic and gastroprokinetic activities were evaluated. Among them, N-(1-ethylhexahydroazepin-3-yl)-, N-(1-ethyloctahydroazocin-3-yl)- and N-(1- ethyloctahydroazonin-3-yl)-6-methoxy-1H-benzotriazole-5-carboxamides (24, 36, 37) showed a potent antiemetic activity (inhibition of apomorphine-induced emesis in dogs) along with gastroprokinetic activity (gastric emptying in rats).