86731-89-7

Basic information

• Product Name: Glycine, N-forMyl-N-(phenylMethyl)-
• Synonyms: Glycine, N-forMyl-N-(phenylMethyl)-
• CAS NO: 86731-89-7
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.19924
• Mol File: 86731-89-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Glycine, N-forMyl-N-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-forMyl-N-(phenylMethyl)-(86731-89-7)
• EPA Substance Registry System: Glycine, N-forMyl-N-(phenylMethyl)-(86731-89-7)

Safety Data

• Hazardous Substances Data: 86731-89-7(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 298-12-4 Glyoxilic acid 
• 100-46-9 benzylamine 
• 6436-90-4 ethyl 2-(benzylamino)acetate 

Downstream Products

• 86731-90-0 1-benzyl-pyrrole-3,4-dicarboxylic acid 
• 78394-12-4 1-Benzyl-1H-pyrrol-3,4-dicarbonsaeuredimethylester 
• 7689-50-1 N-benzyl glycine hydrochloride 
• 92763-89-8 (1-Benzyl-4-hydroxymethyl-1H-pyrrol-3-yl)-methanol 
• 92763-72-9 1-benzyl-1H-pyrrole-3,4-dicarbaldehyde 
• 92763-74-1 2-Benzyl-6,7-dihydro-2H-benzo[f]isoindole-5,8-dione 
• 92763-78-5 2,8-Dibenzyl-2H,8H-2,8-diaza-dicyclopenta[b,i]anthracene-5,11-dione 

Relevant articles and documents

Structure-property relationship study of n-(hydroxy)peptides for the design of self-assembled parallel β-sheets

The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a remarkably short β-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These peptide- peptoid hybrids form unique parallel β-sheet structures by selfassembly upon hydrogenation. Our spectroscopic and crystallographic data suggest that the local conformational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand hydrogen bonds.

Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives

A simple and industrially viable process for preparing a 1-substituted pyrrole-3-carboxylic acid derivative of formula (I) is provided. The process comprises reacting a compound of formula (II), a compound of formula (III), and an acid anhydride according

Experiments towards the Synthesis of the Ergot Alkaloids and Related Structures. Part 6. N-Acyl-N-(1,2,3,4-tetrahydro-1-oxo-2-naphthyl)glycines and a New Aromatisation Reaction

Three methods are reported for the preparation of N-(1,2,3,4-tetrahydro-1-oxo-2-naphthyl)glycine (4; R=H) hydrochloride from which the title compounds may be prepared.In the first, hydrolysis of the oxazolinone ester (3; R=CH2CO2Me, n=1) with concentrated hydrochloric acid in acetic acid furnished a mixture (ca. 4:1) of the hydrochlorides of the required amino-keto-acid (4; R=H) and β-naphthylglycine (5; R1=R2=H) which were easily separable.In the second, a similar hydrolysis of the homologous oxazinedione (3; R=CH2CO2Me, n=2) furnished it as the sole product in quantitative yield.In the third, 2-aminotetralone hydrochloride (7) was treated in formic acid solution with glyoxylic acid (ca. 3 mol equiv.) in the presence of base to give the N-formyl-keto-acid (10=4; R=CHO) in a crude yield of 85percent and from which the hydrochloride of (4; R=H) was obtained by hydrolysis.Benzylamine reacted similarly to give N-formyl-N-benzylglycine but secondary amines do not appear to undergo this novel condensation-reduction reaction.Uncatalysed formolysis of the oxazolinone ester (3; R=CH2CO2Me, n=1) furnished, in essentially quantitative yield, methyl N-formyl-2-naphthylglycinate (5; R1=CHO, R2=Me) - a new aromatisation reaction which may well be of general utility since the parent oxazolinone and its N-methyl derivative behaved similarly.