86784-80-7

Basic information

• Product Name: CRF (HUMAN, RAT)
• Synonyms: SER-GLU-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-MET-GLU-ILE-ILE-NH2;SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2;CORTICOTROPIN RELEASING FACTOR;CORTICOTROPIN RELEASING FACTOR (CRF), HUMAN, RAT;CORTICOTROPIN RELEASING FACTOR, HUMAN;CORTICOTROPIN RELEASING FACTOR, HUMAN AND RAT;CORTICOTROPIN RELEASING FACTOR HUMAN, RAT;CRF, HUMAN AND RAT
• CAS NO: 86784-80-7
• Molecular Formula: C208H344N60O63S2
• Molecular Weight: 4757.45
• Product Categories: Peptide;CRF receptor and related;proteins
• Mol File: 86784-80-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: CRF (HUMAN, RAT)(CAS DataBase Reference)
• NIST Chemistry Reference: CRF (HUMAN, RAT)(86784-80-7)
• EPA Substance Registry System: CRF (HUMAN, RAT)(86784-80-7)

Safety Data

• WGK Germany: 3
• RTECS: GM7925000
• F: 10
• Hazardous Substances Data: 86784-80-7(Hazardous Substances Data)

Usage

Description

Corticotropin-releasing factor (CRF) is a 41-amino-acid polypeptide that plays a crucial role in the body's stress response. It is expressed in neurons, hypothalamus, and amygdala, and is involved in regulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the production of cortisol in the adrenal cortex. CRF is also found in various species, including humans and rats.

Uses

Used in Cell Culture Applications:
CRF (HUMAN, RAT) is used as a component in Dulbecco's modified eagle medium (DMEM) for incubating lung explants and as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells. This helps in studying the growth and development of lung cells under controlled conditions.
Used in Peptide Synthesis:
CRF (HUMAN, RAT) is used in the synthesis of the corticotropin-releasing factor (CRF)-TAMRA conjugate, which is a fluorescently labeled version of the peptide. This conjugate can be used for various research purposes, such as studying the binding and localization of CRF in biological systems.
Used in Neurobiological Research:
CRF (HUMAN, RAT) is used in chronic intracerebroventricular administration to study its effect on hypoxia in the hippocampus. This helps researchers understand the role of CRF in the brain's response to low oxygen levels and its potential implications in neurological disorders.
Used in Pharmaceutical Industry:
CRF (HUMAN, RAT) is used in the treatment of symptoms associated with peritumoral edema in brain tumor patients. It may help in reducing the swelling and pressure around the tumor, providing relief to the patients.
Brand Name:
Xerecept (Hollister-Stier) is a brand name for Corticotropin Releasing Factor, and it is important to indicate the source of the product (human, porcine, etc.) in the labeling.

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

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