868407-50-5

Basic information

• Product Name: (E)-3-(2-amino-4-chlorophenyl)-acrylic acid
• Synonyms: (E)-3-(2-amino-4-chlorophenyl)-acrylic acid
• CAS NO: 868407-50-5
• Molecular Weight: 197.621
• Mol File: 868407-50-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-amino-4-chlorophenyl)-acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-amino-4-chlorophenyl)-acrylic acid(868407-50-5)
• EPA Substance Registry System: (E)-3-(2-amino-4-chlorophenyl)-acrylic acid(868407-50-5)

Safety Data

• Hazardous Substances Data: 868407-50-5(Hazardous Substances Data)

Upstream product

• 150869-41-3 methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 

Downstream Products

• 685534-24-1 (E)-3-(2-amino-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]-propenone 
• 945027-72-5 C₂₇H₂₇ClN₃FO₄ 
• 868407-49-2 (E)-3-[4-chloro-2-(2,2,2-trifluoroacetylamino)-phenyl]-acrylic acid 
• 868407-51-6 (E)-9-{3-[4-chloro-2-(2,2,2-trifluoroacetylamino)-phenyl]-acryloyl}-7-(4-fluorobenzyl)-3,7,9-triazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists

Design and synthesis of a series of 3-amino-4-(2-(2-(4-benzylpiperazin-1-yl)-2-oxoethoxy)phenylamino)cyclobutenedione derivatives as novel CCR1 antagonists are described. Structure-activity relationship studies led to the identification of compound 22, which demonstrated potent binding activity, functional antagonism of CCR1 as well as good species cross-reactivity. In addition, compound 22 also showed desirable pharmacokinetic profiles and was selected for in vivo studies in the mouse collagen-induced arthritis model.