86847-67-8

Basic information

• Product Name: 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine
• Synonyms: 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine
• CAS NO: 86847-67-8
• Molecular Formula: C₁₇H₂₀N₂O₂
• Molecular Weight: 284.3529
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 86847-67-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine(86847-67-8)
• EPA Substance Registry System: 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine(86847-67-8)

Safety Data

• Hazardous Substances Data: 86847-67-8(Hazardous Substances Data)

Usage

Description

2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine, with the chemical formula C14H16N2O2 and CAS number 86847-67-8, is an organic compound characterized by the presence of a pivaloylamino group at the 2-position and an α-hydroxybenzyl group at the 3-position of the pyridine ring. This unique molecular structure endows it with potential applications in various fields, particularly in organic synthesis.

Uses

Used in Organic Synthesis:
2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine is used as a synthetic intermediate for the preparation of various organic compounds. Its versatile structure allows for further functionalization and modification, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine is used as a key component in the development of novel drug candidates. Its unique structure can be exploited to design and synthesize new molecules with potential therapeutic applications, such as antimicrobial, antiviral, or anticancer agents.
Used in Agrochemical Industry:
2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine is also utilized in the agrochemical industry as a precursor for the synthesis of new pesticides or herbicides. Its structural features can be tailored to create compounds with improved efficacy and selectivity against target pests or weeds.

Upstream product

• 86847-59-8 2-(pivaloylamino)pyridine 
• 100-52-7 benzaldehyde 
• 504-29-0 2-aminopyridine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 125867-32-5 phenyl (2-pivaloylamino-3-pyridyl) ketone 
• 3810-10-4 2-amino-3-benzoylpyridine 
• 125867-44-9 5-phenyl-6,7,8,9-tetrahydrobenzo<1,8>naphthiridine 
• 28721-30-4 4-phenyl-1,2-dihydropyrido<2,3-d>-2-pyrimidinone 

Relevant articles and documents

PROTEIN KINASE INHIBITORS

The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; V is sulpur or carbon; R3 is oxygen or fluorine; R4 is an optionally present C1-3 alkyl group optionally substituted by fluorine; R5 is an optionally present cyclic group with 5-7 heavy atoms in the ring which may be carbocyclic or heterocyclic and aromatic or aliphatic and is optionally substituted, e.g. by a halogen, C1-2 alkyl or fluoroalkyl, OH, OR6, cyano, COOR6, CONHR6, sulfonamide or NHR6, in which R6 is a C1-2 alkyl or fluoroalkyl; at least one of R4 and R5 is present and R4 and R5 may both be present; m and n are each 1 or 2 depending on the identity of V and R3; when n=2 each R3 may be the same or different but are preferably the same, when m=2, each R4 and each R5 may be the same or different but are preferably the same; and W represents hydrogen, carbon, nitrogen, oxygen or sulphur; or incorporating a salt, hydrate or solvate of a group of formula (I); as well as therapeutic uses of these compounds, in particular as inhibitors of protein kinase activity and in the treatment of inflammation, inflammatory conditions and cancer.

Synthesis and structure-activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT)

The synthesis and structure-activity relationships of N-phenyl-N′-[3- (4-phenylnaphthylidinoyl)]urea derivatives 3 as a novel structural class of potent ACAT inhibitors is described. A 3-methoxy group substituted on the naphthylidinone 4-phenyl ring, toge

Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives

The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.