86847-77-0

Basic information

• Product Name: Propanamide, 2,2-dimethyl-N-(4-methyl-2-pyridinyl)-
• CAS NO: 86847-77-0
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• Mol File: 86847-77-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanamide, 2,2-dimethyl-N-(4-methyl-2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2,2-dimethyl-N-(4-methyl-2-pyridinyl)-(86847-77-0)
• EPA Substance Registry System: Propanamide, 2,2-dimethyl-N-(4-methyl-2-pyridinyl)-(86847-77-0)

Safety Data

• Hazardous Substances Data: 86847-77-0(Hazardous Substances Data)

Upstream product

• 121953-44-4 (1-Benzotriazol-1-yl-2,2-dimethyl-propyl)-(4-methyl-pyridin-2-yl)-amine 
• 695-34-1 2-Amino-4-methylpyridine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1569-17-1 4-methyl[1,8]-naphthyridine 
• 850014-29-8 N-(3-bromo-4-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 893566-37-5 N-(5-chloro-4-methylpyridin-2-yl)pivalamide 
• 179554-99-5 (2-amino-4-methylpyridin-3-yl)methanol 
• 51564-92-2 2-amino-6-chloro-4-methylpyridine 
• 1004294-60-3 N-(6-chloro-4-methylpyridin-2-yl)pivalamide 

Relevant articles and documents

Rhodium(III)-catalyzed oxidative olefination of pyridines and quinolines: Multigram-scale synthesis of naphthyridinones

A Rh(III)-catalyzed oxidative olefination of pyridines and quinolines has been achieved. This method has a broad substrate scope and has been applied to the expeditious, multigram-scale synthesis of naphthyridinones.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

The Chemistry of N-Substituted Benzotriazoles. Part 20. Mono-N-t-Butylation of Aromatic and Heteroaromatic Amines

Adducts R1CH(Bt)NHAr, readily available from aldehydes, primary aromatic or heteroaromatic amines, and benzotriazole are converted by H2O2-SeO2 into mixtures of R1CONHAr and HCONR1Ar in proportions which depend rationally on the nature of the R1 group.For R1=But, the formamide HCON(But)Ar is formed in satisfactory yields thus enabling the title reaction to be achieved.