868546-91-2Relevant articles and documents
Convergent approaches for the synthesis of the antitumoral peptide, Kahalalide F. study of orthogonal protecting groups
Gracia, Carolina,Isidro-Llobet, Albert,Cruz, Luis J.,Acosta, Gerardo A.,Alvarez, Mercedes,Cuevas, Carmen,Giralt, Ernest,Albericio, Fernando
, p. 7196 - 7204 (2008/02/01)
Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show antitumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution.