868620-36-4

Basic information

• Product Name: 4-[(3-nitrobenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
• CAS NO: 868620-36-4
• Molecular Weight: 331.331
• Mol File: 868620-36-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(3-nitrobenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(3-nitrobenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide(868620-36-4)
• EPA Substance Registry System: 4-[(3-nitrobenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide(868620-36-4)

Safety Data

• Hazardous Substances Data: 868620-36-4(Hazardous Substances Data)

Upstream product

• 139755-99-0 1-methyl-3-propyl-1 H-pyrazole-5-carboxylic acid 
• 865855-32-9 4-bromo-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 
• 645-09-0 3-nitrobenzamide 
• 128537-50-8 4-bromo-1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

A modified, economical and efficient synthesis of variably substituted pyrazolo[4,3-d]pyrimidin-7-ones

1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid (3) was exclusively brominated at the 4-position by bromine in the dark. Brominated product 8 was then converted into 1-methyl-3-propyl-1H-pyrazole-5-carboxamide 9 by successive treatment with thionyl chloride and ammonium hydroxide. Carboxamide 9 was treated with various aroyl amides under microwave (MW) irradiation to afford 4-aroylamino-1-methyl-3-propyl-1H-pyrazole-5-carboxamides 10-22 and 5-aryl-1-methyl-3-propyl-1,6-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7-ones 23-35. The 1H-pyrazole-5-carboxamides 10-22 were also converted to pyrimidinones 23-35 either by conventional heating or by MW irradiation. However, MW irradiation method gives excellent yields in very short time.