86886-82-0 Usage
Description
N-(3,4-dichlorophenyl)-4-methylbenzamide is a benzamide derivative with a molecular formula of C14H11Cl2NO. It is a white to off-white solid that is insoluble in water but soluble in organic solvents. This chemical compound is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and agrochemical products. Its structure and properties, including potential biological and pharmacological activities such as analgesic and antipyretic properties, make it a valuable and versatile tool in the field of medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Industry:
N-(3,4-dichlorophenyl)-4-methylbenzamide is used as a pharmaceutical intermediate for the synthesis of various drugs and agrochemical products. Its versatile chemical structure allows for the development of new compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
N-(3,4-dichlorophenyl)-4-methylbenzamide is used as a valuable tool in medicinal chemistry for the exploration of its potential biological and pharmacological activities. Its analgesic and antipyretic properties make it a promising candidate for the development of new medications to treat pain and fever.
Used in Drug Development:
N-(3,4-dichlorophenyl)-4-methylbenzamide is utilized in drug development to create new compounds with potential therapeutic benefits. Its unique structure and properties contribute to the advancement of pharmaceutical research and the discovery of innovative treatments for various health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 86886-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,8,8 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 86886-82:
(7*8)+(6*6)+(5*8)+(4*8)+(3*6)+(2*8)+(1*2)=200
200 % 10 = 0
So 86886-82-0 is a valid CAS Registry Number.
86886-82-0Relevant articles and documents
Design, synthesis and structure-activity relationship of new HSL inhibitors guided by pharmacophore models
Al-Shawabkeh, Jumana D.,Al-Nadaf, Afaf H.,Dahabiyeh, Lina A.,Taha, Mutasem O.
, p. 127 - 145 (2014/03/21)
Hormone-sensitive lipase (HSL) is a critical enzyme involved in the hormonally regulated release of fatty acids and glycerol from adipocyte lipid stores. Its inhibition may improve insulin sensitivity and blood glucose handling in type 2 diabetes. Accordingly, many small-molecule HSL inhibitors have recently been identified. In continuation of our efforts for discovery of new HSL inhibitors, we prepared a variety of esters, amides, sulfonamides and sulfonate esters capable of fitting two pharmacophore models that we developed and published earlier. The tested compounds were synthesized via coupling reactions of aroyl chlorides or sulfonyl chlorides with phenols, amines and related derivatives. Our efforts led to the identification of interesting compounds of low micromolar anti-HSL bioactivities, which have potential to be developed into effective antidiabetic agents.
