869066-83-1

Basic information

• Product Name: 2-(1-Hydroxymethylcyclopropyl)acetic acid
• Synonyms: 2-(1-Hydroxymethylcyclopropyl)acetic acid;1-(hydroxymethyl)Cyclopropaneacetic acid
• CAS NO: 869066-83-1
• Molecular Formula: C6H10O3
• Molecular Weight: 130.1418
• Mol File: 869066-83-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 289.7°C at 760 mmHg
• Flash Point: 143.3°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.000237mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 2-(1-Hydroxymethylcyclopropyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Hydroxymethylcyclopropyl)acetic acid(869066-83-1)
• EPA Substance Registry System: 2-(1-Hydroxymethylcyclopropyl)acetic acid(869066-83-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 869066-83-1(Hazardous Substances Data)

Usage

General Description

2-(1-Hydroxymethylcyclopropyl)acetic acid, otherwise known as HMCPA, is a chemical compound with the formula C7H10O3. It is categorized as a carboxylic acid and contains a hydroxyl group, a cyclopropyl group, and an acetic acid group within its structure. It is colorless, appears solid at room temperature, and is widely used in chemical science and pharmaceutical research due to its unique reactive properties. Research surrounding this compound primarily revolves around its application in the synthesis of other complex molecules. Safety data regarding this chemical indicates that it should be handled with care as it can cause skin irritation, severe eye irritation, and may also cause respiratory irritation if inhaled.

InChI:InChI=1/C6H10O3/c7-4-6(1-2-6)3-5(8)9/h7H,1-4H2,(H,8,9)

Upstream product

• 152922-71-9 1-(hydroxymethyl)cyclopropaneacetonitrile 
• 20156-74-5 bromomethylcyclopropyl acetate 

Downstream Products

• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 

Relevant articles and documents

Synthesis method and application of 1-hydroxymethyl cyclopropyl acetic acid

The invention provides a synthetic method of 1-hydroxymethyl cyclopropyl acetic acid, which is an important intermediate of montelukast sodium serving as a raw material. The method comprises the following steps: by taking a compound bromomethyl cyclopropyl acetate as an initial raw material, preparing a Grignard reagent from the compound bromomethyl cyclopropyl acetate and magnesium strips or magnesium chips or magnesium powder under the initiation of an initiator; in the same reaction system, performing nucleophilic addition with dried carbon dioxide to prepare a compound, namely magnesium acetate bromide cyclopropyl ester; and carrying out ester hydrolysis on the magnesium bromide acetate cyclopropyl ester under an alkaline condition to obtain the 1-hydroxymethyl cyclopropyl acetic acid.The cost is effectively reduced; and synthesis steps are reduced, high-risk operation in the synthesis process is removed, safety risks are reduced, and environmental pollution is reduced.

SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.