869093-85-6Relevant articles and documents
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists
Sandham, David A.,Aldcroft, Clive,Baettig, Urs,Barker, Lucy,Beer, David,Bhalay, Gurdip,Brown, Zarin,Dubois, Gerald,Budd, David,Bidlake, Louise,Campbell, Emma,Cox, Brian,Everatt, Brian,Harrison, David,Leblanc, Catherine J.,Manini, Jodie,Profit, Rachael,Stringer, Rowan,Thompson, Katy S.,Turner, Katharine L.,Tweed, Morris F.,Walker, Christoph,Watson, Simon J.,Whitebread, Steven,Willis, Jennifer,Williams, Gareth,Wilson, Caroline
, p. 4347 - 4350 (2008/12/20)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
