869101-60-0Relevant articles and documents
Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
Lee, Su-Lin,Huang, Wei-Jan,Lin, Wan Wan,Lee, Shoei-Sheng,Chen, Chung-Hsiung
, p. 6175 - 6181 (2007/10/03)
Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 μM.