869347-40-0Relevant articles and documents
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity
Fattorusso, Caterina,Gemma, Sandra,Butini, Stefania,Huleatt, Paul,Catalanotti, Bruno,Persico, Marco,De Angelis, Meri,Fiorini, Isabella,Nacci, Vito,Ramunno, Anna,Rodriquez, Manuela,Greco, Giovanni,Novellino, Ettore,Bergamini, Alberto,Marini, Stefano,Coletta, Massimo,Maga, Giovanni,Spadari, Silvio,Campiani, Giuseppe
, p. 7153 - 7165 (2007/10/03)
Pyrrolobenzoxazepinones (PBOs) represent a new class of human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) whose prototype is 5. Molecular modeling studies based on the X-ray structures of HIV-1 RT pro