869357-67-5

Basic information

• Product Name: 2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester
• Synonyms: 2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester
• CAS NO: 869357-67-5
• Molecular Weight: 416.191
• Mol File: 869357-67-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester(869357-67-5)
• EPA Substance Registry System: 2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester(869357-67-5)

Safety Data

• Hazardous Substances Data: 869357-67-5(Hazardous Substances Data)

Upstream product

• 869357-64-2 methyl 2-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 29632-74-4 2-fluro-4-iodoaniline 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 869357-63-1 methyl 5-bromo-2-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 853109-24-7 methyl 2-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 38025-90-0 2-chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid 

Downstream Products

• 934639-06-2 2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-N-(2-(vinyloxy)ethoxy)-1,6-dihydropyridine-3-carboxamide 
• 869357-68-6 2-[(2-fluoro-4-iodoiodophenyl)amino]-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide 
• 1181809-21-1 2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid 

Relevant articles and documents

Azacyclo compound serving as protein kinase inhibitor and preparation method of azacyclo compound

The invention relates to an azacyclo compound serving as a protein kinase inhibitor and a preparation method of the azacyclo compound, namely a compound shown as a formula (I) and pharmaceutically acceptable salts, prodrugs and solvates thereof, and in the formula, R1, R2, R3, R4 and X are as defined in the specification. The compound is a protein kinase inhibitor, particularly a protein kinase inhibitor Mek inhibitor, and is useful in the treatment of cancer and inflammation in mammals. The invention also discloses a preparation method of the compound as shown in the formula (I) and a pharmaceutical composition containing the compound.

DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS

This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N'-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.

COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER

This invention relates to a combination product comprising a MEK inhibitor and a B-raf inhibitor, and to methods for the production of an anti-cancer effect in a patient, which is accordingly useful in the treatment of cancer in a patient. More specifically the present invention relates to: a combination product comprising a MEK inhibitor and a B raf inhibitor; a combination product comprising a kit of parts comprising a MEK inhibitor and a B-raf inhibitor; use of the combination product in the treatment of cancer; a method of treating cancer comprising administering the combination product to a patient. The combination product and methods of the invention are also useful in the treatment of other diseases associated with the activity of MEK, and/or B-raf.