869468-34-8

Basic information

• Product Name: (+)-(4R)-4-[(tert-butoxycarbonyl)amino]pentan-2-one
• Synonyms: (+)-(4R)-4-[(tert-butoxycarbonyl)amino]pentan-2-one
• CAS NO: 869468-34-8
• Molecular Weight: 201.266
• Mol File: 869468-34-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-(4R)-4-[(tert-butoxycarbonyl)amino]pentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(4R)-4-[(tert-butoxycarbonyl)amino]pentan-2-one(869468-34-8)
• EPA Substance Registry System: (+)-(4R)-4-[(tert-butoxycarbonyl)amino]pentan-2-one(869468-34-8)

Safety Data

• Hazardous Substances Data: 869468-34-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 869468-33-7 (+)-(1'S,2'S,3R)-3-(tert-butoxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)butanamide 
• 917-54-4 methyllithium 

Downstream Products

• 159991-23-8 (R)-3-((tert-butoxycarbonyl)amino)butanoic acid 
• 934525-68-5 C₁₈H₂₈N₂O₃ 

Relevant articles and documents

3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramid e analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes

Based on the structures of NVP-DPP728 (1) and NVP-LAF237 (Vildagliptin, 2), three series of DPP-IV inhibitors were synthesized by linking substituted anilines, benzylamines, and phenylethylamines to (2S)-cyanopyrrolidine through a linker. More than 20 compounds were evaluated for their in vitro DPP-IV inhibition and selectivity profile over DPP-II, DPP8, and FAP enzymes. Selected compounds 5f and 7i showed in vivo plasma DPP-IV inhibition and inhibited glucose excursion in OGTT after oral administration in Wistar rats. Compound 5f (DPP-IV IC50 = 116 nM) has the potential for development as antidiabetic agent.