869570-00-3

Basic information

• Product Name: BOC-L-4-BR-PHE-NITRILE
• Synonyms: BOC-L-4-BR-PHE-NITRILE;Boc-Phe(4-Br)-Nitrile;(2S)-2-(tert-Butoxycarbonylamino)-3-(4-bromophenyl)propanenitrile;Boc-L-4-Bromophenylalaninenitrile
• CAS NO: 869570-00-3
• Molecular Formula: C₁₄H₁₇BrN₂O₂
• Molecular Weight: 325.204
• Mol File: 869570-00-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 458.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.335
• PKA: 9.86±0.46(Predicted)
• CAS DataBase Reference: BOC-L-4-BR-PHE-NITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-4-BR-PHE-NITRILE(869570-00-3)
• EPA Substance Registry System: BOC-L-4-BR-PHE-NITRILE(869570-00-3)

Safety Data

• Hazardous Substances Data: 869570-00-3(Hazardous Substances Data)

Usage

Description

BOC-L-4-BR-PHE-NITRILE is a chemical compound that is a nitrile derivative of the amino acid phenylalanine. It is commonly used in organic chemistry research and synthesis as a building block in the synthesis of peptides and other organic molecules. The "BOC" in its name refers to the t-butoxycarbonyl protecting group attached to the amino group of the phenylalanine, which makes it more stable and easier to handle in reactions. The "4-BR" indicates that there is a bromine atom attached to the fourth carbon of the phenylalanine side chain.
Used in Pharmaceutical Industry:
BOC-L-4-BR-PHE-NITRILE is used as a building block for the development and production of pharmaceuticals. Its unique structure and functional groups make it a valuable component in the synthesis of various drug molecules.
Used in Agrochemical Industry:
BOC-L-4-BR-PHE-NITRILE is also used in the development and production of agrochemicals. Its properties and reactivity make it suitable for the synthesis of various agrochemical compounds.
Used in Fine Chemicals Industry:
BOC-L-4-BR-PHE-NITRILE is used as a building block in the synthesis of other fine chemicals. Its versatility and stability make it an important component in the production of various specialty chemicals.

Upstream product

• 24250-84-8 H-p-BrPhe-OH 
• 24424-99-5 di-tert-butyl dicarbonate 
• 62129-39-9 4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine 
• 266306-18-7 (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 869569-99-3 tert-butyl (S)-(1-amino-3-(4-bromophenyl)-1-oxopropan-2-yl)carbamate 

Downstream Products

• 1398717-93-5 (S)-D₆-1-amino-N-(1-cyano-2-(4'-((4-methyl-piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 
• 1398717-97-9 (R)-1-amino-N-(1-cyano-2-(4'-((4-propylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 
• 1398717-99-1 (R)-1-amino-N-(1-cyano-2-(4'-((4-cyclopropyl-piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 
• 1398718-01-8 (R)-1-amino-N-(1-cyano-2-(4'-((4-(cyanomethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 
• 1398718-36-9 (S)-(9H-fluoren-9-yl)methyl 1-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)-biphenyl-4-yl)ethylcarbamoyl)cyclohexylcarbamate 
• 1398717-81-1 (S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 
• 1398718-50-7 (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate 
• 1398718-52-9 (S)-(9H-fluoren-9-yl)methyl 1-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)cyclopentylcarbamate 
• 1398718-54-1 (S)-tert-butyl 2-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-2,3-dihydro-1H-inden-2-ylcarbamate 
• 1398796-17-2 (S)-(9H-fluoren-9-yl)methyl 2-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)bicyclo[2.2.1]heptan-2-ylcarbamate 
• 1398718-57-4 (S)-D₆-(9H-fluoren-9-yl)methyl 1-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)cyclohexylcarbamate 
• 1398717-87-7 (S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide 
• 1398717-89-9 (S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclopentanecarboxamide 
• 1398717-91-3 (S)-2-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-2,3-dihydro-1H-indene-2-carboxamide 

Relevant articles and documents

UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea compound or the pharmacologically acceptable salt thereof, and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.

PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS

The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions comprising said compounds, and methods of treatment involving said compounds.

PEPTIDYL NITRILCOMPOUNDS AS PEPTIDASE INHIBITORS

The invention relates to compounds of Formula (II) and their use in theraphy as peptidase inhibitors.