86963-38-4

Basic information

• Product Name: (-)-1-Phenylethanesulfonic acid
• Synonyms: (-)-1-Phenylethanesulfonic acid;(S)-alpha-Methylbenzenemethanesulfonic acid
• CAS NO: 86963-38-4
• Molecular Formula: C₈H₁₀O₃S
• Molecular Weight: 186.2282
• Mol File: 86963-38-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-1-Phenylethanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-1-Phenylethanesulfonic acid(86963-38-4)
• EPA Substance Registry System: (-)-1-Phenylethanesulfonic acid(86963-38-4)

Safety Data

• Hazardous Substances Data: 86963-38-4(Hazardous Substances Data)

Usage

General Description

(-)-1-Phenylethanesulfonic acid is a chiral organic compound with the molecular formula C8H10O3S. It is a white solid that is soluble in water, and is often used as a chiral resolving agent in chiral chromatography. (-)-1-Phenylethanesulfonic acid is commonly employed as a resolving agent for amines and alcohols, as it forms diastereomeric salts with chiral compounds, allowing for their separation based on differences in solubility. (-)-1-Phenylethanesulfonic acid has a variety of industrial and laboratory applications, and its chiral nature makes it a valuable tool in the study and production of chiral compounds.

Upstream product

• 62258-06-4 thioacetic acid S-((S)-1-phenylethyl) ester 
• 86963-39-5 L-HPG*(-)-PES 
• 33877-11-1 1-Phenylethanethiol 
• 98-85-1 1-Phenylethanol 
• 29850-82-6 (+/-)-(S)-(1-phenyl-ethyl)-isothiourea; hydrobromide 
• 5877-96-3 methyl α-phenylmethanesulfonate 
• 1939-99-7 benzenesulfonyl chloride 

Downstream Products

• 143602-76-0 (S)-1-Phenyl-ethanesulfonic acid methyl ester 
• 121769-71-9 (S)-1-Phenyl-ethanesulfonic acid; compound with (R)-2-amino-succinic acid 4-methyl ester 
• 121769-69-5 (S)-1-Phenyl-ethanesulfonic acid; compound with (S)-2-amino-succinic acid 4-methyl ester 

Relevant articles and documents

Rh/Wudaphos-Catalyzed Asymmetric Hydrogenation of Sodium α-Arylethenylsulfonates: A Method to Access Chiral α-Arylethylsulfonic Acids

A highly enantioselective hydrogenation of various sodium α-arylethenylsulfonates catalyzed by Rh/chiral ferrocenyl bisphosphorus ligand (Wudaphos) was successfully developed to construct a series of chiral α-arylethylsulfonic acids in the presence of CF3SO3H with full conversion and good to excellent enantioselectivity (>99% conversion, up to 96% ee) under mild reaction conditions for the first time. Moreover, the control experiment results showed that the non-covalent ion pair interaction between the α-arylethenylsulfonic acid and the Wudaphos ligand plays an important role in this asymmetric hydrogenation system.

ENANTIOSELECTIVE ROUTES TO CHIRAL BENZYLIC THIOLS, SULFINIC ESTERS AND SULFONIC ACIDS ILLUSTRATED BY THE 1-PHENYLETHYL SERIES

Chiral benzylic thiols, sulfinic esters and sulfonic acids can be produced readily and in excellent enantiomeric purity from the corresponding achiral ketones.