869671-60-3Relevant articles and documents
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
Dong, Yuxiang,Tang, Yuanqing,Chollet, Jacques,Matile, Hugues,Wittlin, Sergio,Charman, Susan A.,Charman, William N.,Tomas, Josefina Santo,Scheurer, Christian,Snyder, Christopher,Scorneaux, Bernard,Bajpai, Saroj,Alexander, Scott A.,Wang, Xiaofang,Padmanilayam, Maniyan,Cheruku, Srinivasa R.,Brun, Reto,Vennerstrom, Jonathan L.
, p. 6368 - 6382 (2007/10/03)
Based on the structures of several lipophilic trioxolane antimalarial prototypes, we set out to determine which functional groups were associated with good antimalarial profiles and identify more polar (lower Log P/Log D) lead compounds with good physicoc