869951-15-5

Basic information

• Product Name: 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID;4-bromo-5-propylthiophene-2-carboxylic acid(SALTDATA: FREE);4-bromo-5-propyl-2-thenoic acid;4-bromo-5-propyl-2-thiophenecarboxylic acid
• CAS NO: 869951-15-5
• Molecular Formula: C₈H₉BrO₂S
• Molecular Weight: 249.13
• Mol File: 869951-15-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 345°C at 760 mmHg
• Flash Point: 162.5°C
• Appearance: /
• Density: 1.587g/cm³
• Vapor Pressure: 2.41E-05mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID(869951-15-5)
• EPA Substance Registry System: 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID(869951-15-5)

Safety Data

• Hazardous Substances Data: 869951-15-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9BrO2S/c1-2-3-6-5(9)4-7(12-6)8(10)11/h4H,2-3H2,1H3,(H,10,11)

Upstream product

• 1256286-47-1 ethyl 4-bromo-5-propylthiophene-2-carboxylate 

Downstream Products

• 1047628-69-2 4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-propyl-2-thiophenecarboxamide 
• 1047628-77-2 4-(1,4-dimethyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-propyl-2-thiophenecarboxamide 
• 1047628-72-7 4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-propyl-2-thiophenecarboxamide 
• 1047627-36-0 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-5-propyl-2-thiophenecarboxamide 
• 1047627-37-1 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-propyl-2-thiophenecarboxamide 
• 1047627-38-2 N-{(1S)-2-amino-1-[2-(trifluoromethyl)benzyl]ethyl}-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-propylthiophene-2-carboxamide 

Relevant articles and documents

Direct bromination of ethyl 5-alkylthiophene-2-carboxylates

Approaches to brominated thiophene-2-carboxylic acids by electrophilic bromination of the corresponding acids and esters were compared and investigated. A synthetic route was developed involving direct bromination of ethyl 5-alkylthiophene-2-carboxylates followed by saponification of the resulting ethyl 5-alkyl-4-bromothiophene-2-carboxylates. The key bromination step is selective in dichloromethane solution at 0-5 °C and furnishes the corresponding ethyl 5-alkyl-4-bromothiophene-2-carboxylates in excellent yields. No migration or isomerization of the alkyl substituents was observed. Georg Thieme Verlag Stuttgart New York.