87-16-1Relevant articles and documents
Synthesis of salicylates from anionically activated aromatic trifluoromethyl group
Lin, Chuankai,Liu, Jin-Biao,Wang, Ruixiang,Xie, Huilin
supporting information, (2021/12/22)
An efficient approach to salicylates via a novel transformation of anionically activated aromatic trifluoromethyl group is described. Anionically activated trifluoromethyl group can react with phenols/alcohols under alkaline conditions to afford aryl/alkyl salicylates in high yields. Mechanism studies indicate that the carbonyl oxygen atom of ester is from the H2O in the solvent.
Preparation method for guacetisal
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Paragraph 0068-0070; 0076; 0077; 0083; 0084; 0090; 0091, (2017/08/29)
The invention discloses a preparation method for guacetisal. The preparation method comprises the following steps: with salicylic acid as a starting material, activating salicylic acid with N,N'-carbonyldiimidazole; then reacting activated salicylic acid with guaiacol so as to obtain guaiacol salicylate; and carrying out hydroxyacetylation so as to obtain guacetisal. The preparation method provided by the invention has the following advantages: the preparation method is formulated via improvement of conventional synthetic routes; the preparation method avoids usage of reagents with great toxicity and strong irritation, such as phosphorous oxychloride, thionyl chloride and phosgene; reaction temperature is substantially lowered; reaction conditions are mild; and the method is simple to operate. It is unexpectedly discovered in the invention that a novel crystal form of guacetisal is prepared by using the preparation method; and compared with conventional crystal forms, the novel crystal form improves the water-solubility and stability of guacetisal, allows the contents of related substances to be substantially reduced, and greatly improved medication security.
A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids
Gonzalez-Gomez, Jose C.,Ramirez, Nieves P.,Lana-Villarreal, Teresa,Bonete, Pedro
supporting information, p. 9680 - 9684 (2017/11/30)
We report on the use of visible light photoredox catalysis for the radical Smiles rearrangement of 2-aryloxybenzoic acids to obtain aryl salicylates. The method is free of noble metals and operationally simple and the reaction can be run under mild batch or flow conditions. Being a redox neutral process, no stoichiometric oxidants or reductants are needed.