870194-97-1

Basic information

• Product Name: [3-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester
• Synonyms: [3-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester
• CAS NO: 870194-97-1
• Molecular Weight: 193.202
• Mol File: 870194-97-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester(870194-97-1)
• EPA Substance Registry System: [3-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester(870194-97-1)

Safety Data

• Hazardous Substances Data: 870194-97-1(Hazardous Substances Data)

Upstream product

• 147283-87-2 methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate 
• 52798-00-2 (3-cyano-phenyl)-acetic acid methyl ester 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 621-37-4 m-hydroxyphenylacetic acid 
• 142327-44-4 methyl 3-formylphenylacetate 

Downstream Products

• 927187-57-3 (3-{5-(2-chloro-phenyl)-4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 927187-56-2 (3-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-o-tolyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 870194-96-0 LC₁₇₆₅ 
• 927187-54-0 (3-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-furan-2-yl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 927187-47-1 (3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 927187-53-9 (3-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-isopropyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 

Relevant articles and documents

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists. Part 2

A series of PPARδ-selective agonists was investigated and optimized for a favorable in vivo pharmacokinetic profile. Isoxazole LCI765 (17d) was found to be a potent and selective PPARδ agonist with good in vivo PK properties in mouse (Cmax = 5.1 μM, t1/2 = 3.1 h). LCI765 regulated expression of genes involved in energy homeostasis in relevant tissues when dosed orally in C57BL6 mice. A co-crystal structure of compound LCI765 and the LBD of PPARδ is discussed.