870238-67-8

Basic information

• Product Name: 2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
• Synonyms: BENZONITRILE,2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-;2-(4-Cyano-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Cyano-3-fluorophenylboronic acid pinacol ester;2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborola;2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;4-Cyano-3-fluorobenzeneboronic acid pinacol ester, 96%
• CAS NO: 870238-67-8
• Molecular Formula: C₁₃H₁₅BFNO₂
• Molecular Weight: 247.0731032
• Mol File: 870238-67-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 346.6±32.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(870238-67-8)
• EPA Substance Registry System: 2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(870238-67-8)

Safety Data

• Hazardous Substances Data: 870238-67-8(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a chemical compound composed of a benzonitrile group with a fluorine atom at the 2 position and a boron-based dioxaborolane group at the 4 position. 2-Fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile has potential applications in organic synthesis and pharmaceutical research due to its unique structure and properties. It is commonly used as a building block in the synthesis of complex organic molecules and as a ligand in catalytic processes. The presence of the fluorine atom and the boron-based group makes this compound valuable in the development of new materials and pharmaceutical compounds.

Upstream product

• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 73183-34-3 bis(pinacol)diborane 
• 843663-18-3 (4-cyano-3-fluorophenyl)boronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 57381-51-8 4-chloro-2-fluorobenzonitrile 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 898803-05-9 3-[2-tert-Butoxycarbonylamino-2-(4'-cyano-3'-fluoro-biphenyl-3-yl)-ethyl]-benzoic acid methyl ester 
• 1129540-59-5 4-(2-chloropyrimidin-4-yl)-2-fluorobenzonitrile 
• 1197377-47-1 4-(3-amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 
• 1221541-29-2 C₃₀H₃₂F₄N₄O₄S 
• 1227910-73-7 4-(2-amino-6-{[(2-chlorophenyl)methyl]amino}-4-pyrimidinyl)-2-fluorobenzonitrile 
• 1227910-86-2 4-(2-amino-6-{[1-(phenylmethyl)cyclopropyl]amino}-4-pyrimidinyl)-2-fluorobenzonitrile 
• 1227910-90-8 4-{2-amino-6-[(1,1-dimethyl-2-phenylethyl)amino]-4-pyrimidinyl}-2-fluorobenzonitrile 
• 1227910-96-4 4-(2-amino-6-{methyl[(1R)-1-methyl-2-phenylethyl]amino}-4-pyrimidinyl)-2-fluorobenzonitrile 
• 1227910-98-6 4-[2-amino-6-(2,3-dihydro-1H-inden-1-ylamino)-4-pyrimidinyl]-2-fluorobenzonitrile 
• 1227911-92-3 4-(2-amino-6-{2-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-4-morpholinyl}-4-pyrimidinyl)-2-fluorobenzonitrile 
• 1227911-99-0 4-{2-amino-6-[2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-4-morpholinyl]-4-pyrimidinyl}-2-fluorobenzonitrile 
• 1227912-05-1 4-{2-amino-6-[2-(4-phenyl-1H-imidazol-2-yl)-4-morpholinyl]-4-pyrimidinyl}-2-fluorobenzonitrile 
• 1227912-11-9 4-(2-amino-6-{2-[4-(3-chlorophenyl)-1H-imidazol-2-yl]-4-morpholinyl}-4-pyrimidinyl)-2-fluorobenzonitrile 

Relevant articles and documents

COMPOUNDS

A compound of formula (I), or a pharmaceutical salt thereof.

ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Palladium- or nickel-catalyzed coupling reaction of dialkoxyboranes with chloroarenes: arylation of 1,3,2-dioxaborolanes or l,3,2-dioxaborinanes

The borylation of electron-deficient aryl chlorides with pinacolborane proceeded in the presence of BU4NI and a catalytic amount of Pd(dba)2 / bis(2-di-tert-butylphosphinophenyl) ether. The combination of NiCl2(dppp) catalyst and Bu4NBr was also efficient for the borylation of aryl chlorides.