87039-48-3

Basic information

• Product Name: 6-Methoxy-5-nitroquinazoline
• Synonyms: 6-Methoxy-5-nitroquinazoline
• CAS NO: 87039-48-3
• Molecular Formula: C9H7N3O3
• Molecular Weight: 205.172
• Mol File: 87039-48-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 169 °C
• Boiling Point: 381.2°C at 760 mmHg
• Flash Point: 184.4°C
• Appearance: /
• Density: 1.406g/cm³
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: 2-8°C
• PKA: 3.43±0.39(Predicted)
• CAS DataBase Reference: 6-Methoxy-5-nitroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-5-nitroquinazoline(87039-48-3)
• EPA Substance Registry System: 6-Methoxy-5-nitroquinazoline(87039-48-3)

Safety Data

• Hazardous Substances Data: 87039-48-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7N3O3/c1-15-8-3-2-7-6(4-10-5-11-7)9(8)12(13)14/h2-5H,1H3

Upstream product

• 7556-92-5 6-Methoxy-chinazolin 

Relevant articles and documents

Heterocyclic Quinones. 4. A New Highly Cytotoxic Drug: 6,7-Bis(1-aziridinyl)-5,8-quinazolinedione

With the aim of obtaining new antitumoral agents, a series of 5,8-quinazolinediones was prepared. 5-Amino-6-methoxyquinazoline was oxidized by Fremy's salt to give 6-methoxy-5,8-quinazolinedione.Nucleophilic substitution reaction at C6, electrophilic substitution at C7, and synthesis of 7-amino-6-methoxy-5,8-quinazolinedione, the parent compound of streptonigrin, were studied.These compounds were tested for cytotoxic properties on L1210 leukemia cells in vitro.One of them, 6,7-bis(1-aziridinyl)-5,8-quinazolinedione, which exhibits a high cytotoxic activity (ID50=0.08 μM), was further screened in standard antitumor systems, including L1210 leukemia, P388 lymphocytic leukemia, sarcoma 180, and B16 melanocarcinoma.This drug gives a significant antitumoral effect on P388 leukemia but is inactive on other experimental models.Moreover, this compound was found to be highly mutagenic for Salmonella typhimurium TA98 and TA100 strains (Ames test), suggesting that DNA damage could be responsible for its cytotoxicity.