87052-60-6

Basic information

• Product Name: Z-(S)-Val-Cl
• Synonyms: Z-(S)-Val-Cl
• CAS NO: 87052-60-6
• Molecular Weight: 269.728
• Mol File: 87052-60-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Z-(S)-Val-Cl(CAS DataBase Reference)
• NIST Chemistry Reference: Z-(S)-Val-Cl(87052-60-6)
• EPA Substance Registry System: Z-(S)-Val-Cl(87052-60-6)

Safety Data

• Hazardous Substances Data: 87052-60-6(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 111881-67-5 [(S)-1-(2-Hydroxymethyl-phenylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 78452-06-9 [(S)-1-((3S,8aR)-3-Benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 78452-06-9 [(S)-1-((3S,8aS)-3-Benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 114744-84-2 N^α-(benzyloxycarbonyl)-N-methoxy-N-methyl-L-valinamide 
• 1259946-37-6 C₁₅H₂₃N₃O₃ 
• 1259945-70-4 N-(benzyloxycarbonyl)-valyl-methylazalanine-nitrile 
• 73871-08-6 Z-L-Val-δ-Z-L-Orn-OH 
• 111881-36-8 {(S)-1-[2-(1H-Benzoimidazol-2-ylsulfanylmethyl)-phenylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester 
• 111881-50-6 (S)-2-Amino-N-[2-(1H-benzoimidazole-2-sulfinylmethyl)-phenyl]-3-methyl-butyramide 
• 111881-43-7 (S)-2-Amino-N-[2-(1H-benzoimidazol-2-ylsulfanylmethyl)-phenyl]-3-methyl-butyramide 
• 78452-07-0 (L-Valyl)-L-phenylalanyl-D-prolin-lactam 
• 78452-07-0 (L-Valyl)-L-phenylalanyl-L-prolin-lactam 
• 50868-53-6 (6aS,9R)-7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid [(S)-1-((3S,8aR)-3-benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-2-methyl-propyl]-amide 
• 50868-53-6 N-(d-Lysergyl-L-valyl)-L-phenylalanyl-D-prolin-lactam 

Relevant articles and documents

Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors

Using the example of cathepsin K, we demonstrate the design of highly potent and selective azadipeptide nitrile inhibitors. A systematic scan with respect to P2 and P3 substituents was carried out. Structural modifications strongly affected the enzyme-inh

One-pot synthesis of Weinreb amides employing 3,3-dichloro-1,2-diphenylcyclopropene (CPI-Cl) as a chlorinating agent

The synthesis of Nα-protected amino alkyl Weinreb amides starting from the corresponding α-amino acids as well as carboxylic acids has been delineated through the in situ generation of acid chlorides using CPI-Cl as a chlorinating agent. The protocol is simple; the reaction conditions employed were mild, and compatible with all the three commonly used urethane protecting groups namely, Boc, Cbz and Fmoc groups. The resulting Weinreb amides are obtained in good yields as optically pure products.

Amino acid amides of 2-benzimidazole as acid-stable prodrugs of potential inhibitors of H+/K+ ATPase

A series of amino acid amides of 2-benzimidazole were prepared and found to possess gastric antisecretory activity on oral administration. (Glycylaminobenzyl)sulfinyl compound 23a, stable in artificial gastric juice (pH 1.2), was given orally to dogs.It was absorbed efficiently and converted into aniline derivative 7a which showed a very high plasma concentration.Compound 23a was hydrolyzed by the action of aminopeptidase present in plasma or the brush border fraction of the small intestine to release the terminal glycine. o-Aniline derivatives showed good activity in in vitro H+/K+-ATPase inhibition as well as in the inhibition of histamine stimulated acid secretion in isolated bullfrog gastric mucosa.Although these o-aniline derivatives showed no or weak gastric antisecretory activity in rat by id administration, they were active when administered ip.Therefore, these amino acid amides were considered to be acid stable prodrugs of proton pump inhibiting o-aniline derivatives.The mechanism of H+/K+-ATPase inhibition of 7a was also examined.