87067-06-9

Basic information

• Product Name: 1,2,3,3a-tetrahydro-5H-Pyrrolo[1,2-a][3,1]benzoxazine
• Synonyms: 1,2,3,3a-tetrahydro-5H-Pyrrolo[1,2-a][3,1]benzoxazine
• CAS NO: 87067-06-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 87067-06-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,3a-tetrahydro-5H-Pyrrolo[1,2-a][3,1]benzoxazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,3a-tetrahydro-5H-Pyrrolo[1,2-a][3,1]benzoxazine(87067-06-9)
• EPA Substance Registry System: 1,2,3,3a-tetrahydro-5H-Pyrrolo[1,2-a][3,1]benzoxazine(87067-06-9)

Safety Data

• Hazardous Substances Data: 87067-06-9(Hazardous Substances Data)

Upstream product

• 73051-88-4 [2-(pyrrolidin-1-yl)phenyl]methanol 
• 58028-74-3 2-pyrrolidin-1-ylbenzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1374603-83-4 (2-(2-(3,3-dimethylbut-1-yn-1-yl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-82-3 (2-(2-(oct-1-yn-1-yl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-87-8 (2-(2-(mesitylethynyl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-89-0 (2-(2-(naphthalen-1-ylethynyl)pyrrolidin-1-yl)phenyl)methanol 
• 1179261-38-1 (2-(2-methylpyrrolidin-1-yl)phenyl)methanol 
• 1374603-71-0 (2-(2-vinylpyrrolidin-1-yl)phenyl)methanol 
• 1374603-86-7 (2-(2-(4-((tert-butyldimethylsilyl)oxy)but-1-yn-1-yl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-67-4 (2-(2-isopropylpyrrolidin-1-yl)phenyl)methanol 
• 1374603-64-1 (2-(2-pentylpyrrolidin-1-yl)phenyl)methanol 
• 1374603-85-6 (2-(2-(phenylethynyl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-65-2 (2-(2-phenylpyrrolidin-1-yl)phenyl)methanol 
• 1374603-88-9 (2-(2-((3,5-bis(trifluoromethyl)phenyl)ethynyl)pyrrolidin-1-yl)phenyl)methanol 
• 1391019-94-5 (2-(2-(naphthalen-1-yl)pyrrolidin-1-yl)phenyl)methanol 
• 1374603-68-5 (2-(2-cyclohexylpyrrolidin-1-yl)phenyl)methanol 

Relevant articles and documents

A Catalyzed Aerobic Intramolecular C-O Bond Formation: Facile Access to Ring-Fused Dihydrobenzoxazine Derivatives

A catalyst comprising of catalytic cobalt(II) acetate/copper(II) acetate/ dl -tyrosine with oxygen as the oxidant allows aerobic intramolecular C-O bond construction in [2-(pyrrolidin-1-yl)phenyl]methanol by free-radical promoted intramolecular selective functionalization of an (sp 3)C-H bond by the alcohol, thus providing an environmentally friendly approach to 5 H -benzo[ d ]pyrrolo[2,1- b ][1,3]oxazine derivatives.

N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines

Described herein is an unprecedented N-Alkylation-initiated redox-neutral [5 + 2] annulation of 3-Alkylindoles with o-Aminobenzaldehydes via a cascade N-Alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series of indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields in one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.

Intramolecular redox-triggered C-H functionalization

Sacrifice for the team: A one-pot method achieves remote functionalization at the α-position of an amine moiety through the sacrificial reduction of a neighboring group. The process takes advantage of an intramolecular redox reaction, thereby avoiding the need for any external oxidants. This method was applied to a concise five-step total synthesis of indolizidine 167B.