87080-74-8

Basic information

• Product Name: 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien
• Synonyms: 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien
• CAS NO: 87080-74-8
• Molecular Weight: 598.963
• Mol File: 87080-74-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien(87080-74-8)
• EPA Substance Registry System: 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien(87080-74-8)

Safety Data

• Hazardous Substances Data: 87080-74-8(Hazardous Substances Data)

Upstream product

• 69454-88-2 3β-((tert-butyldimethylsilyl)oxy)-22-hydroxy-23,24-bisn-orchol-5-en 
• 115019-40-4 3β-((tert-butyldimethylsilyl)oxy)-22-hydroxy-23,24-bisn-orchol-5,16(17)-diene 
• 139871-19-5 (3β,17Z)-3-{[(tert-butyl)dimethylsilyl]oxy}-pregna-5,17(20)-diene 
• 42151-23-5 (3S)-3-tert-butyldimethylsilyloxyandrost-5-en-17-one 
• 53-43-0 dehydroepiandrosterone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 57-87-4 Ergosterol 
• 87080-71-5 3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en 
• 87080-69-1 22-Chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en-3β-yl-ethanoat 
• 87080-70-4 22-Chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en-3β-ol 
• 87080-72-6 3β-(tert-Butyldimethylsilyloxy)-23,24-dinorchola-5,7-dien-22-yl-ethanoat 
• 87179-00-8 3β-(tert-Butyldimethylsilyloxy)-22-chlor-23,24-dinorchola-5,7-dien 
• 87080-67-9 22-Chlor-23,24-dinorchola-3,5-dien-3β-yl-ethanoat 
• 74996-92-2 22-Chlor-23,24-dinorchol-5-en-3β-yl-ethanoat 

Downstream Products

• 1715-86-2 cholesta-5,7,24-triene-3β-ol 
• 19356-17-3 calcidiol 

Relevant articles and documents

Synthesis of 25-hydroxyprovitamin D3 from ergosterol: A mild method for the cleavage of hetero Diels-Alder adducts leading to steroidal 5,7-dienes

A new efficient seven-step procedure is described for the preparation of 3β,25-dihydroxy-cholesta-5,7-diene (7) from ergosterol (1) in a total yield of 30%. The 3-hydroxy function of ergosterol (1) is protected as tert- butyldimethylsilyl ether and the 5,

Synthesis and biological evaluation of novel steroidal 5α,8α-endoperoxide derivatives with aliphatic side-chain as potential anticancer agents

By inspiration of significant anti-cancer activity of our previously screened natural ergosterol peroxide (EP), a series of novel steroidal 5α,8α-endoperoxide derivatives 5a–d and 14a–f were designed, synthesized, and biologically evaluated for their in vitro anti-proliferative inhibitory and cytotoxic activity. The results revealed that most of these compounds showed moderate-to-excellent anti-proliferative effects against the tested cancer cell lines (i.e. HepG2, SK-Hep1, MDA-MB-231 and MCF-7). Among them, compound 5b and 14d exhibited preferable inhibitory activities (IC50 of 5b and 14d are 8.07 and 9.50?μM against HepG2, respectively). The structure-activity relationships indicated that incorporation the peroxidic bridge to the steroid scaffolds at C-5 and C-8 positions together with the aliphatic side-chain at the C-17 position would provide synergistic effect for the bioactivity.

Synthesis of 7,8-didehydrodesmosterol

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