871266-78-3 Usage
Description
(7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)PHENYLAMINE is a heterocyclic aromatic compound characterized by the presence of a thiazole ring and a phenylamine group. It has a molecular formula of C11H8ClN5S and a molecular weight of 261.7 g/mol. This chemical compound is commonly utilized in the field of medicinal chemistry for the development of pharmaceuticals. Its unique chemical structure endows it with a range of potential properties and activities, making it a subject of interest for researchers in the pharmaceutical industry. Further research is being conducted to explore its potential applications.
Uses
Used in Pharmaceutical Industry:
(7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)PHENYLAMINE is used as a key component in the development of pharmaceuticals for various medical conditions. Its unique chemical structure allows it to potentially exhibit a range of biological activities, making it a valuable asset in the creation of new and effective treatments.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)PHENYLAMINE serves as a crucial compound for research purposes. Its potential biological activities and interactions with other molecules make it an important subject of study, with the aim of understanding its full potential and identifying possible applications in the development of new drugs and therapies.
Used in Drug Design and Synthesis:
(7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)PHENYLAMINE is employed as a building block in the design and synthesis of new drugs. Its unique chemical properties and potential biological activities make it a valuable component in the creation of novel pharmaceutical compounds with specific therapeutic targets.
Used in Drug Discovery:
As a heterocyclic aromatic compound, (7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)PHENYLAMINE plays a significant role in drug discovery. Its potential to exhibit various properties and activities makes it a promising candidate for the identification of new drug targets and the development of innovative therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 871266-78-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,2,6 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 871266-78:
(8*8)+(7*7)+(6*1)+(5*2)+(4*6)+(3*6)+(2*7)+(1*8)=193
193 % 10 = 3
So 871266-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H7ClN4S/c12-9-8-10(14-6-13-9)17-11(16-8)15-7-4-2-1-3-5-7/h1-6H,(H,15,16)
871266-78-3Relevant articles and documents
Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling
Bharate, Sandip B.,Singh, Baljinder,Kachler, Sonja,Oliveira, Ana,Kumar, Vikas,Bharate, Sonali S.,Vishwakarma, Ram A.,Klotz, Karl-Norbert,Gutiérrez De Terán, Hugo
, p. 5922 - 5928 (2016)
We describe the identification of 7-(prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as a novel chemotype of non-nucleoside partial agonists for the A2A adenosine receptor (A2AAR). Molecular-modeling indicated that the (S)-2-hydroxymethylene-pyrrolidine could mimic the interactions of agonists' ribose, suggesting that this class of compounds could have agonistic properties. This was confirmed by functional assays on the A2AAR, where their efficacy could be associated with the presence of the 2-hydroxymethylene moiety. Additionally, the best compound displays promising affinity, selectivity profile, and physicochemical properties.
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists
Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Xiao, Wei,Peterson, Matthew L.,Nasser, Nadia,Maher, Michael P.,Ao, Hong,Bhattacharya, Anindya,Kansagara, Mena,Scott, Brian P.,Luo, Lin,Rynberg, Raymond,Rizzolio, Michele,Chaplan, Sandra R.,Wickenden, Alan D.,Guy Breitenbucher
scheme or table, p. 40 - 46 (2009/04/10)
We have identified and synthesized a series of 2,7-diamino-thiazolo[5,4-d]pyrimidines as TRPV1 antagonists. An exploration of the structure-activity relationships at the 2-, 5-, and 7-positions of the thiazolo[5,4-d]pyrimidine led to the identification of
Single-step syntheses of 2-amino-7-chlorothiazolo[5,4-d]pyrimidines: Intermediates for bivalent thiazolopyrimidines
Liu, Jian,Patch, Raymond J.,Schubert, Carsten,Player, Mark R.
, p. 10194 - 10197 (2007/10/03)
A single-step process for the preparation of 2-amino-7-chlorothiazolo[5,4- d]pyrimidines, 2, was achieved by the reaction of the commercially available 4,6-dichloro-5-aminopyrimidine 1 with isothiocyanates. This mild reaction accommodates a variety of fun
