87129-71-3 Usage
Originator
Arnolol,ZYF Pharm Chemical
Manufacturing Process
2 methods of producing of 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-
methyl-butan-2-ol:
1). 19.0 g of 1-[4-(2-methoxyethyl)phenoxy]-3-nitro-3-methylbutan-2-ol are
hydrogenated at 60°C and under a pressure of 6 bar in a mixture of 250 ml of
ethanol and 50 ml of glacial acetic acid in the presence of 4.0 g of palladiumon-
charcoal (10% Pd). After the mixture has been filtered and the solvent has
been evaporated off, the residue is rendered alkaline with 2 N NaOH and the mixture is extracted with CH2Cl2. The organic phase is washed with water and
dried with Na2SO4 to give, after evaporation, 15.0 g of the 1-[4-(2-
methoxyethyl)phenoxy]-3-amino-3-methylbutan-2-ol, melting point 120°-
122°C (dec.).
2). 18.3 g of zinc dust are gradually added to 20.0 g of 1-[4-(2-methoxyethyl)
phenoxy]-3-nitro-3-methylbutan-2-ol in 400 ml of ethanol and 60 ml of
concentrated hydrochloric acid at 50°-60°C. The mixture is stirred at this
temperature for 1 h and filtered and the solvent is evaporated off. After 200
ml of 40% strength NaOH have been added, the product is extracted with
methylene chloride. Solvent is distilled and the 1-[4-(2-methoxyethyl)
phenoxy]-3-amino-3-methylbutan-2-ol is produced, melting point 120°-122°C
(dec.).
Therapeutic Function
Beta-adrenergic blocker (ophthalmic)
Check Digit Verification of cas no
The CAS Registry Mumber 87129-71-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,1,2 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 87129-71:
(7*8)+(6*7)+(5*1)+(4*2)+(3*9)+(2*7)+(1*1)=153
153 % 10 = 3
So 87129-71-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H23NO3/c1-14(2,15)13(16)10-18-12-6-4-11(5-7-12)8-9-17-3/h4-7,13,16H,8-10,15H2,1-3H3
87129-71-3Relevant articles and documents
Substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines, and intermediate products
-
, (2008/06/13)
New substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines of the general formula I STR1 in which R1 and R2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R1/su
