871339-60-5Relevant articles and documents
Synthesis and SAR of tolylamine 5-HT6 antagonists
Singer, Jamie M.,Wilson, Michael W.,Johnson, Paul D.,Graham, Shelley R.,Cooke, Leonard W.,Roof, Robin L.,Boxer, Peter A.,Gold, Lisa H.,Meltzer, Leonard T.,Janssen, Ann,Roush, Nicole,Campbell, Jeffrey E.,Su, Ti-Zhi,Hurst, Susan I.,Stoner, Chad L.,Schwarz, Jacob B.
scheme or table, p. 2409 - 2412 (2009/12/25)
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were modulated and the effect on potency at 5-HT6 examin