871366-23-3

Basic information

• Product Name: 5-acetyl-2-pyridinecarboxaldehyde
• CAS NO: 871366-23-3
• Molecular Weight: 149.149
• Mol File: 871366-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-acetyl-2-pyridinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetyl-2-pyridinecarboxaldehyde(871366-23-3)
• EPA Substance Registry System: 5-acetyl-2-pyridinecarboxaldehyde(871366-23-3)

Safety Data

• Hazardous Substances Data: 871366-23-3(Hazardous Substances Data)

Upstream product

• 139042-59-4 1-(6-bromopyridin-3-yl)ethanone 
• 624-28-2 2,5-dibromopyridine 
• 287116-76-1 2-bromo-5-(2-methyl-[1,3]dioxolan-2-yl)-pyridine 
• 287116-77-2 5-(2-methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxaldehyde 

Relevant articles and documents

Preparation and antioxidant activity of α-pyridoin and its derivatives

Focusing on α-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) as the lead compound of the novel antioxidative enediol, we synthesized 5,5′- or 6,6′-bis-substituted derivatives of 1 from disubstituted pyridines. The antioxidant activity of 1 and its synthetic derivatives 2-7 was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl radical) scavenging assay and inhibition of lipid peroxidation. In the DPPH assay, 1 exhibited an activity stronger than that of ascorbic acid, and 5,5′-dimethyl-(5) or 5,5′-dimethoxy- substituted derivatives (6) exhibited more potent activity than 1. The DPPH scavenging activities of α-pyridoins were correlated with their oxidation potential and thus the electron density of enediol. 5 and 6 effectively inhibited lipid peroxidation in the rat liver microsome/tert-butyl hydroperoxide system. Therefore, 5 and 6 serve as good candidates for a pharmacologically useful enediol antioxidant.