871656-48-3

Basic information

• Product Name: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid
• Synonyms: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid
• CAS NO: 871656-48-3
• Molecular Weight: 480.654
• Mol File: 871656-48-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid(871656-48-3)
• EPA Substance Registry System: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid(871656-48-3)

Safety Data

• Hazardous Substances Data: 871656-48-3(Hazardous Substances Data)

Upstream product

• 752242-47-0 5-((1S)-2-(tert-butyldimethylsiloxy)-1-methylethoxy)-3-(4-methanesulfonylphenoxy)benzoic acid methyl ester 
• 1001419-66-4 C₂₅H₂₆O₇S 
• 1001419-67-5 3-[(1S)-2-benzyloxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 136918-07-5 (2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol 
• 54915-31-0 methyl 3-(benzyloxy)-5-hydroxybenzoate 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 871656-49-4 methyl 3-(benzyloxy)-5-(4-(methylsulfonyl)phenoxy)benzoate 
• 752242-45-8 3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester 
• 1001419-70-0 C₁₇H₁₈O₇S 

Downstream Products

• 1001419-72-2 C₂₅H₂₆O₈S 
• 1093120-78-5 C₂₇H₂₃N₃O₇S₂ 
• 1093120-80-9 C₂₇H₂₄N₂O₉S₂ 
• 1093120-79-6 C₂₇H₂₅N₃O₈S₂ 
• 1093120-77-4 C₂₇H₂₄N₂O₉S₂ 
• 1093121-27-7 C₃₄H₄₀N₂O₉S₂Si 
• 871656-50-7 3-[(1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy]-N-[4-(methoxymethyl)-1,3-thiazol-2-yl]-5-[4-(methylsulfonyl)phenoxy]benzamide 
• 871656-47-2 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide 

Relevant articles and documents

1, 3 - DIHYDROXY SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS

Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is alkyl, aryl, arylalkyl, heteroaryl, or he

HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

Compounds of Formula (I) wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.