871690-72-1

Basic information

• Product Name: 3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)aniline
• Synonyms: 3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)aniline
• CAS NO: 871690-72-1
• Molecular Weight: 260.292
• Mol File: 871690-72-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)aniline(871690-72-1)
• EPA Substance Registry System: 3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)aniline(871690-72-1)

Safety Data

• Hazardous Substances Data: 871690-72-1(Hazardous Substances Data)

Upstream product

• 69627-03-8 7-chlorothieno[3,2-b]pyridine 
• 69627-02-7 thieno[3,2-b]pyridin-7(4H)-one 
• 913377-45-4 2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione 
• 403-19-0 2-fluoro-4-nitrophenol 
• 399-96-2 4-amino-2-fluorophenol 

Relevant articles and documents

Design, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction

In our continuing efforts to develop novel c-Met inhibitors as potential anticancer candidates, a series of new N-sulfonylamidine derivatives were designed, synthesized via Cu-catalyzed multicomponent reaction (MCR) as the key step, and evaluated for their in vitro biological activities against c-Met kinase and four cancer cell lines (A549, HT-29, MKN-45 and MDA-MB-231). Most of the target compounds showed moderate to significant potency at both the enzyme-based and cell-based assay and possessed selectivity for A549 and HT-29 cancer cell lines. The preliminary SAR studies demonstrated that compound 26af (c-Met IC50 = 2.89 nM) was the most promising compound compared with the positive foretinib, which exhibited the remarkable antiproliferative activities, with IC50 values ranging from 0.28 to 0.72 μM. Mechanistic studies of 26af showed the anticancer activity was closely related to the blocking phosphorylation of c-Met, leading to cell cycle arresting at G2/M phase and apoptosis of A549 cells by a concentration-dependent manner. The promising compound 26af was further identified as a relatively selective inhibitor of c-Met kinase, which also possessed an acceptable safety profile and favorable pharmacokinetic properties in BALB/c mouse. The favorable drug-likeness of 26af suggested that N-sulfonylamidines may be used as a promising scaffold for antitumor drug development. Additionally, the docking study and molecular dynamics simulations of 26af revealed a common mode of interaction with the binding site of c-Met. These positive results indicated that compound 26af is a potential anti-cancer candidate for clinical trials, and deserves further development as a selective c-Met inhibitor.

Heterobicyclic thiophene compounds and methods of use

Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

ETHER-LINKED HETEROARYL COMPOUNDS

Compounds of formula (I) are disclosed, as well as methods for synthesizing such compounds and methods of their use. Preferred compounds of formula (I) are potent inhibitors of c-MET/HGFR useful in the treatment of a variety of HGFR-mediated disorders, including cancers.