871726-72-6 Usage
Description
4-[(Dimethylamino)methylene]-3-oxo-1-piperidinecarboxylic acid tert-butyl ester is a dipeptide derivative with the molecular formula C15H25N3O3. It is a chemical compound that features a tert-butyl ester group attached to the carboxylic acid functional group and a dimethylamino group, which imparts unique chemical properties to the molecule. 4-[(Dimethylamino)methylene]-3-oxo-1-piperidinecarboxylic acid tert-butyl ester is commonly used as a reagent in organic synthesis and requires careful handling and adherence to safety protocols due to its potential reactivity and hazardous nature.
Uses
Used in Organic Synthesis:
4-[(Dimethylamino)methylene]-3-oxo-1-piperidinecarboxylic acid tert-butyl ester is used as a reagent in organic synthesis for its unique chemical properties conferred by the dimethylamino group. It plays a crucial role in a variety of chemical reactions, facilitating the synthesis of complex organic molecules and contributing to the development of new compounds with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-[(Dimethylamino)methylene]-3-oxo-1-piperidinecarboxylic acid tert-butyl ester is used as an intermediate in the synthesis of various drug molecules. Its unique structure and reactivity make it a valuable component in the development of new medications, potentially leading to the creation of innovative treatments for a range of medical conditions.
Used in Chemical Research:
4-[(Dimethylamino)methylene]-3-oxo-1-piperidinecarboxylic acid tert-butyl ester is also utilized in chemical research as a model compound to study the properties and reactions of similar dipeptide derivatives. This research can lead to a better understanding of the underlying chemical mechanisms and contribute to the advancement of synthetic chemistry and the discovery of new chemical compounds with practical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 871726-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,7,2 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 871726-72:
(8*8)+(7*7)+(6*1)+(5*7)+(4*2)+(3*6)+(2*7)+(1*2)=196
196 % 10 = 6
So 871726-72-6 is a valid CAS Registry Number.
871726-72-6Relevant articles and documents
Tetrahydropyrido[3,4-d]pyrimidine compounds as well as preparation method and application thereof
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Paragraph 0041-0045; 0064; 0069; 0074; 0080; 0087; 0101, (2017/07/19)
The invention provides tetrahydropyrido[3,4-d]pyrimidine compounds as well as a preparation method and an application thereof and belongs to the field of medicinal chemistry. The compounds are 1-(2-(substituent amino)-5,8-dihydropyrido[3,4-d] pyrimidin-7(6H)-yl)-3-substituent prop-2-en-1-one compounds and can be taken as a JAK3 inhibitor. The compounds are 1-(2-(substituent amino)-5,8-dihydropyrido[3,4-d] pyrimidin-7(6H)-yl)-3-substituent prop-2-en-1-one compounds or pharmaceutically acceptable salts or prodrug molecules thereof represented in the structural formula (I) in the specification, wherein E is -H and C1-C3 aliphatic hydrocarbon; R is -H, amino substituted C1-C3 aliphatic hydrocarbon and C4-C6 naphthenic hydrocarbon containing 1-2 N or O heteroatoms. The compounds can be used for treating or preventing various autoimmune system diseases and cancers.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2
Blake, James F.,Gaudino, John J.,De Meese, Jason,Mohr, Peter,Chicarelli, Mark,Tian, Hongqi,Garrey, Rustam,Thomas, Allen,Siedem, Christopher S.,Welch, Michael B.,Kolakowski, Gabrielle,Kaus, Robert,Burkard, Michael,Martinson, Matthew,Chen, Huifen,Dean, Brian,Dudley, Danette A.,Gould, Stephen E.,Pacheco, Patricia,Shahidi-Latham, Sheerin,Wang, Weiru,West, Kristina,Yin, Jianping,Moffat, John,Schwarz, Jacob B.
, p. 2635 - 2639 (2014/06/09)
The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.
