87174-84-3

Basic information

• Product Name: (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-5-hydroxy-pentanoic acid benzyl ester
• CAS NO: 87174-84-3
• Molecular Weight: 463.485
• Mol File: 87174-84-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-5-hydroxy-pentanoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-5-hydroxy-pentanoic acid benzyl ester(87174-84-3)
• EPA Substance Registry System: (S)-2-tert-Butoxycarbonylamino-5-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-5-hydroxy-pentanoic acid benzyl ester(87174-84-3)

Safety Data

• Hazardous Substances Data: 87174-84-3(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 30924-93-7 Boc-Glu-OBn 

Downstream Products

• 26630-55-7 (2S)-L-α-Aminopimelic acid 
• 87174-85-4 benzyl 2-<(tert-butyloxycarbonyl)amino>-5-<5-(2,2-dimethyl-4,6-dioxo-1,3-dioxanyl)>pentanoate 

Relevant articles and documents

Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: Effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity

Chain-extended analogues of methotrexate were synthesized by condensation of 4-amino-4-deoxy-N10-methylpteroic acid with esters of L-α-aminoadipic, L-α-aminopimelic, and L-α-aminosuberic acids, followed by ester hydrolysis with acid or base. Co