87190-76-9

Basic information

• Product Name: 1-(5-O-acetyl-2,3-dideoxy-3-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one
• CAS NO: 87190-76-9
• Molecular Formula: C₁₃H₁₅N₈O₄
• Molecular Weight: 347.3089
• Mol File: 87190-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(5-O-acetyl-2,3-dideoxy-3-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-O-acetyl-2,3-dideoxy-3-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one(87190-76-9)
• EPA Substance Registry System: 1-(5-O-acetyl-2,3-dideoxy-3-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one(87190-76-9)

Safety Data

• Hazardous Substances Data: 87190-76-9(Hazardous Substances Data)

Usage

Chemical structure

The compound is composed of a 1,2,4-triazole ring fused to a pyrimidine ring, as well as a pentofuranosyl moiety.

Functional groups

The compound contains acetyl and dideoxy functional groups, as well as a triaza-dien-ium moiety.

Unique structure

The combination of the 1,2,4-triazole ring, pyrimidine ring, and pentofuranosyl moiety results in a unique and complex structure.

Potential applications

Due to its unique structure and combination of functional groups, the compound may have potential biological or pharmaceutical applications.

Medicinal chemistry

The complex structure and diverse functional groups make it an interesting target for further study and potential application in the field of medicinal chemistry.

Biological activity

Further research is needed to determine the specific biological activities and potential therapeutic uses of this compound.

Synthesis

The synthesis of this complex compound may involve multiple steps and require specialized knowledge in organic chemistry.

Stability

The stability of the compound under various conditions (e.g., temperature, pH, etc.) should be investigated to determine its suitability for potential applications.

Solubility

The solubility of the compound in different solvents may impact its potential use in pharmaceutical formulations.

Toxicity

The toxicity of the compound should be assessed to ensure its safety for potential therapeutic use.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 84472-87-7 3'-azido-2',3'-dideoxy-5'-O-acetyluridine 

Downstream Products

• 84472-90-2 3'-amino-2',3'-dideoxycytidine 
• 84472-89-9 3'-azido-2',3'-dideoxycytidine 

Relevant articles and documents

Synthesis and Biological Activity of Various 3'-Azido and 3'-Amino Analogues of 5-Substituted Pyrimidine Deoxyribonucleosides

Various new 5-substituted 3'-azido- and 3'-amino derivatives of 2'-deoxyuridine and 2'-deoxycytidine have been synthesized and biologically evaluated.Among these compounds, 3'-amino-2',3'-dideoxy-5-fluorouridine (3), 3'-amino-2',3'-dideoxycytidine (7a), and 3'-amino-2',3'-dideoxy-5-fluorocytidine (7c) were found to be the most active against murine L1210 and sarcoma 180 neoplastic cells in vitro, with an ED50 of 15 and 1 μM, 0.7 and 4 μM, and 10 and 1 μM, respectively.The 3'-azido derivatives, 2 and 6c, were less active in comparison with their 3'-amino counterparts.In addition, the 5-fluoro-3'-amino nucleosides, 3 and 7c, were tested against L1210 leukemia bearing CDF1 mice.Our preliminary findings indicate that compound 7c (6 * 200 mg/kg) was as active as the positive control, 5-fluorouracil (6 * 20 mg/kg), yielding a T/C * 100 of 146 and 129, respectively.However, 3 was found to be inactive in this experiment.