872088-10-3

Basic information

• Product Name: (6-CHLOROPYRIDIN-3-YL)-O-TOLYL-METHANONE
• Synonyms: (6-CHLOROPYRIDIN-3-YL)-O-TOLYL-METHANONE;2-Chloro-5-(2-methylbenzoyl)pyridine
• CAS NO: 872088-10-3
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• Product Categories: pharmacetical
• Mol File: 872088-10-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 347.4°C at 760 mmHg
• Flash Point: 163.9°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 5.38E-05mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: (6-CHLOROPYRIDIN-3-YL)-O-TOLYL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-CHLOROPYRIDIN-3-YL)-O-TOLYL-METHANONE(872088-10-3)
• EPA Substance Registry System: (6-CHLOROPYRIDIN-3-YL)-O-TOLYL-METHANONE(872088-10-3)

Safety Data

• Hazardous Substances Data: 872088-10-3(Hazardous Substances Data)

Usage

Description

(6-Chloropyridin-3-yl)-o-tolyl-methanone, a chemical compound with the molecular formula C14H10ClNO, is a white to off-white solid. It is a ketone derivative that features a chloropyridine group and a tolyl group. Its diverse reactivity and compatibility make it a valuable building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it can be used as a key intermediate in the production of fine chemicals and other specialty compounds.

Uses

Used in Pharmaceutical Industry:
(6-Chloropyridin-3-yl)-o-tolyl-methanone is used as a building block for the synthesis of various pharmaceuticals due to its diverse reactivity and compatibility.
Used in Agrochemical Industry:
(6-Chloropyridin-3-yl)-o-tolyl-methanone is used as a building block for the synthesis of various agrochemicals due to its diverse reactivity and compatibility.
Used in Organic Compounds Synthesis:
(6-Chloropyridin-3-yl)-o-tolyl-methanone is used as a key intermediate in the synthesis of various organic compounds, including fine chemicals and specialty compounds, due to its diverse reactivity and compatibility.

InChI:InChI=1/C13H10ClNO/c1-9-4-2-3-5-11(9)13(16)10-6-7-12(14)15-8-10/h2-8H,1H3

Upstream product

• 6699-93-0 (2-methylphenyl)lithium 
• 149281-42-5 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 33872-80-9 o-tolyl magnesium chloride 
• 932-31-0 ortho-tolylmagnesium bromide 

Downstream Products

• 1357305-89-5 3-(2-methylphenyl-2-chloropyrid-5-ylmethoxy)azetidine 
• 1357305-43-1 {3-[(2-methylphenyl)(2-chloropyridin-5-yl)methoxy]azetidin-1-yl}piperidin-1-ylmethanone 
• 1357305-80-6 2-methylphenyl-2-chloropyrid-5-ylmethanol 

Relevant articles and documents

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

We describe here our attempts to optimise the human fatty acid amide hydrolase (FAAH) inhibition and physicochemical properties of our previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084. We describe the SAR of a series of analogues and conclude with the demonstration of in vivo dose-dependant FAAH inhibition in an anandamide-loading study in rats.

Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

Synthesis of 2-aminoimidazo[1,2-a]pyridines 1 and their evaluation as CDK2 inhibitors is described. We have identified a novel structural class of protein serine/threonine kinase inhibitors comprised of an aminoimidazo[1,2-a]pyridine nucleus. Compounds from this family are shown to potently inhibit cyclin-dependent kinases by competing with ATP for binding to a catalytic subunit of the protein. Structure-based design approach was used to direct this chemical scaffold toward generating potent and selective CDK2 inhibitors. The discovery of this new class of ATP-site directed protein kinase inhibitors, aminoimidazo[1,2-a]pyridines, provides the basis of new medicinal chemistry tool in search for an effective treatment of cancer and other diseases that involve protein kinase signaling pathways.