872201-12-2 Usage
Description
K114 is a potent amyloid fibril-specific fluorescent dye, similar to Congo Red and BSB, that recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. It has an affinity for fibrils ranging from 20-30 nM and exhibits minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils.
Uses
Used in Biochemistry and Neuroscience Research:
K114 is used as a fluorescent probe for the detection and analysis of amyloid fibrils in research settings. Its ability to fluoresce in the presence of amyloid fibrils allows for the monitoring of in vitro amyloid fibril formation by fluorescence emission at 550 nm.
Used in Drug Discovery and Development:
K114 can be employed as a tool in the development of drugs targeting amyloid-related diseases, such as Alzheimer's and Parkinson's, by aiding in the identification and evaluation of potential therapeutic agents that interfere with amyloid fibril formation or aggregation.
Used in Diagnostic Applications:
K114 may be utilized in diagnostic assays to detect the presence of amyloid fibrils in biological samples, which could be helpful in the early diagnosis of amyloid-related diseases and monitoring disease progression.
Biological Activity
Potent amyloid fibril-specific fluorescent dye (EC 50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of A β , α -synuclein and tau in situ . (Optimum wavelength = 550 nM).
Check Digit Verification of cas no
The CAS Registry Mumber 872201-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,2,0 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 872201-12:
(8*8)+(7*7)+(6*2)+(5*2)+(4*0)+(3*1)+(2*1)+(1*2)=142
142 % 10 = 2
So 872201-12-2 is a valid CAS Registry Number.
